Zoltán Kutalik and his team are developing statistical methods to gain a greater insight into the genetic mechanisms which influence human traits (such as obesity) or which trigger disorders (such as infectious or autoimmune diseases). The group is particularly interested in the interplay between these genetic factors and the environment. The group’s research topics focus on
1. Genetic fine-mapping: Quantification of multiple genetic effects at a single locus, detecting imperfect tagging, copy number variant associations.
2. Obesity genetics: Age-dependent genetic factors, the time-evolution of genetic effects on obesity, dissecting diet and obesity genetics, revealing genetic effects that depend on the parental origin of the allele.
3. Integration of intermediate markers to gene-disease associations.
4. Genetics of infectious, autoimmune and other diseases.