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Fabienne Tacchini-Cottier, Associate Professor


 

Biography

Fabienne Tacchini-Cottier studied immunology at Stanford University, California, where she obtained her PhD. She then became "maitre-assistante" at the Department of Pathology, University of Geneva. In 1997 she joined the World Health Organization Immunology Research and Training center (WHO-IRTC) in the Department of Biochemistry, University of Lausanne where she is now director of the WHO-IRTC. In 2007 she was promoted Associate Professor ad personam. Since 2011 she is Associate Professor at the Department of Biochemistry, Faculty of Biology and Medicine of the University of Lausanne. Her research interests are 1) the role of the innate immune response in the modulation of Leishmania specific immune responses, with a focus on the role of neutrophils in this process, and 2) the factors determining the differentiation of CD4+ T helper subsets.

Research Interests

IMMUNE RESPONSES TO LEISHMANIA  INFECTION

Mice from the majority of inbred strains (C57BL/6, C3He, Sv129…) are resistant to infection by Leishmania major (L. major), an obligate intracellular protozoan parasite of macrophages in the mammalian host. In contrast, mice from BALB strains are unable to control infection and develop progressive disease. Several subsets of CD4+ T cells distinguishable by the pattern of cytokines they produce in vitro have been described. Among them, Th1 cells are characterized by secretion of IFNγ and LT, while Th2 cells produce IL-4, IL-5 and IL-13. In the murine model of infection with L. major, genetically determined resistance and susceptibility have been clearly shown to result from the appearance of parasite-specific CD4+ T helper 1 (Th1) or T helper 2 (Th2) cells, respectively. This murine model of infection is considered as one of the best experimental system for the study of the mechanisms operating in vivo at the initiation of polarized Th1 and Th2 cell maturation.

Among the several factors influencing Th cell development, cytokines themselves critically regulate this process. Using this model, it has been demonstrated that IL-12 and IL-4 promote Th1 and Th2 cell development, respectively. In addition, cross-talks between different cells at the site of infection also influence the development of a Leishmania-specific immune response.

The aim of our projects is to further investigate the immunological basis accounting for susceptibility or resistance to infection with L. major and other Leishmania species, deciphering the relative importance of different cell populations in protective immunity as well as the different mechanisms involved in T helper differentiation. 

I. Role of neutrophils in the immune response to infection with Leishmania parasites

The development of a protective immune response to microorganisms involves complex interactions between the host and the pathogen. The murine model of infection with L. major allows the study of the parameters leading to the development of a protective immune response. Following infection, most strains of mice are able to heal their lesions, while a few fail to control infection, a process linked to the development of specific subsets of T helper cells, Th1 or Th2 respectively. The mechanisms leading to T helper differentiation are complex and not fully understood.

The early events occurring during the first days of parasite inoculation are thought to be critical in the development of the Leishmania-specific immune response. Neutrophils are the first cells arriving massively to the site of infection, and cumulating evidence points to their role as organizers of the immune response. In the presence of Leishmania, neutrophils from resistant strains of mice secrete distinct cytokines and chemokines influencing the microenvironment at the site of parasite inoculation (Figure 1). Transient depletion of neutrophils was shown to significantly affect the course of infection following inoculation with different Leishmania species. We are currently studying in detail how neutrophils regulate the development of Leishmania-specific immune responses, and investigating the impact of neutrophils in the early events shaping the development of the immune response.

 

Figure 1. L. major induces distinct phenotypes and cytokine secretion in neutrophils from mice resistant (C57BL/6) or susceptible (BALB/c) to infection.

In addition, we recently initiated a study exploring the effects of sandfly salivary gland components on the microenvironment upon parasite inoculation, and we are currently analyzing their impact on the development of Leishmania-specific immune response.

II. Role of Notch signaling in CD4+ T helper differentiation

We are studying CD4+ T helper differentiation for many years, both in vitro and in vivo, using mouse experimental models including cutaneous leishmaniasis models. Recently, we have investigated the role of Notch receptor signaling during CD4+ T helper differentiation. The protective immune response to intracellular parasites involves in most cases the differentiation of IFNγ-secreting CD4+T helper 1 cells. Notch receptors regulate cell differentiation during development but their implication in the polarization of peripheral CD4+ T helper 1 cells is not well understood. Of the four Notch receptors, only Notch1 (N1) and Notch2 (N2) are expressed on activated CD4+ T cells. To investigate the role of Notch in Th1 cell differentiation following parasite infection, mice with T cell-specific gene ablation of N1, N2 or both (N1N2ΔCD4cre) were infected with the protozoan parasite Leishmania major. N1N2ΔCD4cre mice, on the C57BL/6 L. major-resistant genetic background, developed unhealing lesions and uncontrolled parasitemia. Susceptibility correlated with impaired secretion of IFNγ by draining lymph node CD4+ T cells and increased secretion of the Th2 cytokines IL-5 and IL-. Furthermore, we showed that Notch signaling is required for the secretion of IFNγ by Th1 cells, an effect independent of CSL/RBP-Jk, the major effector of Notch receptors, since L. major-infected mice with a RBP-Jk deletion in their T cells were able to develop IFNγ-secreting Th1 cells, kill parasites and heal their lesions. We are currently pursuing these studies, investigating the role of Notch signaling in the differentiation of other CD4+ T helper subsets, using experimental models of infection with Leishmania parasites.

Collaborations. We are currently collaborating with the groups of Dr James Alexander, University of Strathclyde, Glasgow, Scotland; Dr Pascale Kropf, London School of Hygiene and Tropical Medicine, England; Drs Aldina Barral and Camilla Indiani de Oliveira, Fiocruz Institute, Bahia, Brazil; Dr Christoph Mueller, Institute of Pathology, University of Bern; Dr Freddy Radtke (ISREC/EPFL), Lausanne; Dr Robson MacDonald, Ludwig Center for Cancer Research of the UNIL; Dr Hans Acha-Orbea and Dr Sanjiv Luther Department of Biochemisty, Epalinges, UNIL.

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2016
Zamoshnikova A., Groß C.J., Schuster S., Chen K.W., Wilson A., Tacchini-Cottier F., Schroder K., 2016. NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2) pp. 341-346. [DOI] [Pubmed]
2015
Falcão S.A., Weinkopff T., Hurrell B.P., Celes F.S., Curvelo R.P., Prates D.B., Barral A., Borges V.M., Tacchini-Cottier F., de Oliveira C.I., 2015. Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis. PLoS Neglected Tropical Diseases 9(3) pp. e0003601. [DOI] [Web of Science] [Pubmed]
Hurrell B.P., Schuster S., Grün E., Coutaz M., Williams R.A., Held W., Malissen B., Malissen M., Yousefi S., Simon H.U. et al., 2015. Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion. PLoS Pathogens 11(5) pp. e1004929. [DOI] [Web of Science] [Pubmed]
2014
Ashok D., Schuster S., Ronet C., Rosa M., Mack V., Lavanchy C., Marraco S.F., Fasel N., Murphy K.M., Tacchini-Cottier F. et al., 2014. Cross-presenting dendritic cells are required for control of Leishmania major infection. European Journal of Immunology 44(5) pp. 1422-1432. [DOI] [Web of Science] [Pubmed]
Ballet R., Emre Y., Jemelin S., Charmoy M., Tacchini-Cottier F., Imhof B.A., 2014. Blocking Junctional Adhesion Molecule C Enhances Dendritic Cell Migration and Boosts the Immune Responses against Leishmania major. PLoS Pathogens 10(12) pp. e1004550. [DOI] [Web of Science] [Pubmed]
Fasnacht N., Huang H.Y., Koch U., Favre S., Auderset F., Chai Q., Onder L., Kallert S., Pinschewer D.D., MacDonald H.R. et al., 2014. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. Journal of Experimental Medicine 211(11) pp. 2265-2279. [Document] [DOI] [Web of Science] [Pubmed]
Schuster S., Hartley M.A., Tacchini-Cottier F., Ronet C., 2014. A scoring method to standardize lesion monitoring following intra-dermal infection of Leishmania parasites in the murine ear. Frontiers in Cellular and Infection Microbiology 4 p. 67. [DOI] [Web of Science]
von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H. et al., 2014. Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proceedings of the National Academy of Sciences of the United States of America 111(35) pp. 12835-12840. [DOI] [Web of Science] [Pubmed]
Weber B., Schuster S., Zysset D., Rihs S., Dickgreber N., Schürch C., Riether C., Siegrist M., Schneider C., Pawelski H. et al., 2014. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS Pathogens 10(1) pp. e1003900. [DOI] [Web of Science] [Pubmed]
Weinkopff T., de Oliveira C.I., de Carvalho A.M., Hauyon-La Torre Y., Muniz A.C., Miranda J.C., Barral A., Tacchini-Cottier F., 2014. Repeated exposure to Lutzomyia intermedia sand fly saliva induces local expression of interferon-inducible genes both at the site of injection in mice and in human blood. PLoS Neglected Tropical Diseases 8(1) pp. e2627. [DOI] [Web of Science] [Pubmed]
Yang C.Y., Vogt T.K., Favre S., Scarpellino L., Huang H.Y., Tacchini-Cottier F., Luther S.A., 2014. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proceedings of the National Academy of Sciences of the United States of America 111(1) pp. E109-E118. [DOI] [Web of Science] [Pubmed]
2013
Abebe T., Takele Y., Weldegebreal T., Cloke T., Closs E., Corset C., Hailu A., Hailu W., Sisay Y., Corware K. et al., 2013. Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. PLoS Neglected Tropical Diseases 7(3) pp. e2134. [DOI] [Web of Science] [Pubmed]
Auderset F., Schuster S., Fasnacht N., Coutaz M., Charmoy M., Koch U., Favre S., Wilson A., Trottein F., Alexander J. et al., 2013. Notch signaling regulates follicular helper T cell differentiation. Journal of Immunology 191(5) pp. 2344-2350. [DOI] [Web of Science] [Pubmed]
Radtke F., Macdonald H.R., Tacchini-Cottier F., 2013. Regulation of innate and adaptive immunity by Notch. Nature Reviews. Immunology 13(6) pp. 427-437. [DOI] [Web of Science] [Pubmed]
Schuster S., Hurrell B., Tacchini-Cottier F., 2013. Crosstalk between neutrophils and dendritic cells: a context-dependent process. Journal of Leukocyte Biology 94(4) pp. 671-675. [DOI] [Web of Science] [Pubmed]
Takele Y., Abebe T., Weldegebreal T., Hailu A., Hailu W., Hurissa Z., Ali J., Diro E., Sisay Y., Cloke T. et al., 2013. Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection. PLoS Neglected Tropical Diseases 7(1) pp. e1977. [DOI] [Web of Science] [Pubmed]
Weinkopff T., Mariotto A., Simon G., Hauyon-La Torre Y., Auderset F., Schuster S., Zangger H., Fasel N., Barral A., Tacchini-Cottier F., 2013. Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection. Infection and Immunity 81(5) pp. 1575-1584. [DOI] [Web of Science] [Pubmed]
2012
Abebe T., Hailu A., Woldeyes M., Mekonen W., Bilcha K., Cloke T., Fry L., Seich Al Basatena N.K., Corware K., Modolell M. et al., 2012. Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in ethiopia. PLoS Neglected Tropical Diseases 6(6) pp. e1684. [DOI] [Web of Science] [Pubmed]
Auderset F., Coutaz M., Tacchini-Cottier F., 2012. The role of Notch in the differentiation of CD4⁺ T helper cells. Current Topics in Microbiology and Immunology 360 pp. 115-134. [DOI] [Pubmed]
Auderset F., Schuster S., Coutaz M., Koch U., Desgranges F., Merck E., MacDonald H.R., Radtke F., Tacchini-Cottier F., 2012. Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathogens 8(3) pp. e1002560. [DOI] [Web of Science] [Pubmed]
Khan S., Alonso L., Roduit C., Bandyopadhyay S., Singh S., Saha S., Tacchini-Cottier F., Roy S., Dietler G., Kasas S. et al., 2012. Differential peptide binding to CD40 evokes counteractive responses. Human Immunology 73(5) pp. 465-469. [DOI] [Web of Science] [Pubmed]
Mastelic B., Kamath A.T., Fontannaz P., Tougne C., Rochat A.F., Belnoue E., Combescure C., Auderset F., Lambert P.H., Tacchini-Cottier F. et al., 2012. Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants. Journal of Immunology 189(12) pp. 5764-5772. [DOI] [Web of Science] [Pubmed]
2011
Tacchini-Cottier F., van Zandbergen G. (eds.) 2011. Neutrophils in infectious diseases. 79 p., Bentham e Books. [url editor site] [DOI]
Charmoy M, Milon G., Tacchini-Cottier F., 2011. Role of neutrophils in the early shaping of the Leishmania major specific immune response in experimental murine cutaneous Leishmaniasis. pp. 49-58 in Tacchini-Cottier F., van Zandbergen G. (eds.) Neutrophils in infectious diseases. Bentham e Books. [DOI]
Uyttenhove C., Marillier R.G., Tacchini-Cottier F., Charmoy M., Caspi R.R., Damsker J.M., Goriely S., Su D., Van Damme J., Struyf S. et al., 2011. Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection. Journal of Leukocyte Biology 89(6) pp. 1001-1007. [DOI] [Web of Science] [Pubmed]
2010
Charmoy M., Auderset F., Allenbach C., Tacchini-Cottier F., 2010. The prominent role of neutrophils during the initial phase of infection by Leishmania parasites. Journal of Biomedicine and Biotechnology 2010 p. 719361. [Document] [DOI] [Web of Science] [Pubmed]
Charmoy M., Brunner-Agten S., Aebischer D., Auderset F., Launois P., Milon G., Proudfoot A.E., Tacchini-Cottier F., 2010. Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice. PLoS Pathogens 6(2) pp. e1000755. [DOI] [Web of Science] [Pubmed]
Revaz-Breton M., Ronet C., Ives A., Torre Y.H., Masina S., Tacchini-Cottier F., Launois P., 2010. The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major. European Journal of Immunology 40(6) pp. 1697-1707. [DOI] [Web of Science] [Pubmed]
Ronet C., Hauyon-La Torre Y., Revaz-Breton M., Mastelic B., Tacchini-Cottier F., Louis J., Launois P., 2010. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. Journal of Immunology 184(2) pp. 886-894. [Document] [DOI] [Web of Science] [Pubmed]
2009
Bourreau E., Ronet C., Darcissac E., Lise M.C., Sainte Marie D., Clity E., Tacchini-Cottier F., Couppie P., Launois P., 2009. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infection and Immunity 77(4) pp. 1465-1474. [DOI] [Web of Science] [Pubmed]
Bourreau E., Ronet C., Darsissac E., Lise M.C., Marie D.S., Clity E., Tacchini-Cottier F., Couppie P., Launois P., 2009. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. The Journal of Infectious Diseases 199(4) pp. 576-579. [DOI] [Web of Science] [Pubmed]
Chakour R., Allenbach C., Desgranges F., Charmoy M., Mauel J., Garcia I., Launois P., Louis J., Tacchini-Cottier F., 2009. A new function of the Fas-FasL pathway in macrophage activation. Journal of Leukocyte Biology 86(1) pp. 81-90. [DOI] [Web of Science] [Pubmed]
Fiorini E., Merck E., Wilson A., Ferrero I., Jiang W., Koch U., Auderset F., Laurenti E., Tacchini-Cottier F., Pierres M. et al., 2009. Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. Journal of immunology 183(11) pp. 7212-7222. [DOI] [Web of Science] [Pubmed]
2008
Allenbach C., Launois P., Mueller C., Tacchini-Cottier F., 2008. An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection. European Journal of Immunology 38(3) pp. 720-731. [DOI] [Web of Science] [Pubmed]
Launois P., Tacchini-Cottier F., Kieny M.P., 2008. Cutaneous leishmaniasis: progress towards a vaccine. Expert Review of Vaccines 7(8) pp. 1277-1287. [DOI] [Web of Science] [Pubmed]
McFarlane E., Perez C., Charmoy M., Allenbach C., Carter K.C., Alexander J., Tacchini-Cottier F., 2008. Neutrophils contribute to development of a protective immune response during onset of infection with Leishmania donovani. Infection and immunity 76(2) pp. 532-541. [Document] [DOI] [Web of Science] [Pubmed]
Ronet C., Voigt H., Himmelrich H., Doucey M.A., Hauyon-La Torre Y., Revaz-Breton M., Tacchini-Cottier F., Bron C., Louis J., Launois P., 2008. Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice. Journal of Immunology 180(7) pp. 4825-4835. [Document] [Web of Science] [Pubmed]
Tacchini-Cottier F., Launois P., 2008. Host responses to infections with Leishmania. pp. 263-280 in Myler P.J., Fasel N. (eds.) Leishmania : after the Genome. Caister Academic Press, Norfolk.
2007
Bourreau E., Ronet C., Couppié P., Sainte-Marie D., Tacchini-Cottier F., Launois P., 2007. IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes and Infection 9(8) pp. 1034-1041. [DOI] [Web of Science] [Pubmed]
Charmoy M., Megnekou R., Allenbach C., Zweifel C., Perez C., Monnat K., Breton M., Ronet C., Launois P., Tacchini-Cottier F., 2007. Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection. Journal of Leukocyte Biology 82(2) pp. 288-299. [DOI] [Web of Science] [Pubmed]
Kariminia A., Bourreau E., Ronet C., Couppie P., Sainte-Marie D., Tacchini-Cottier F., Launois P., 2007. Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection. Journal of Infectious Diseases 195(5) pp. 739-747. [DOI] [Web of Science] [Pubmed]
Olleros M.L., Vesin D., Martinez-Soria E., Allenbach C., Tacchini-Cottier F., Pache J.C., Marchal G., Rahman J., Fernández C., Izui S. et al., 2007. Interleukin-12p40 overexpression promotes interleukin-12p70 and interleukin-23 formation but does not affect bacille Calmette-Guérin and Mycobacterium tuberculosis clearance. Immunology 122(3) pp. 350-361. [DOI] [Web of Science] [Pubmed]
2006
Allenbach C., Zufferey C., Perez C., Launois P., Mueller C., Tacchini-Cottier F., 2006. Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major. Journal of Immunology 176(11) pp. 6656-6664. [Web of Science] [Pubmed]
Gumy A., Aseffa A., Rachinel N., Breton M., Otten L., Tacchini-Cottier F., Röcken M., Doyen N., Acha-Orbea H., Locksley R.M. et al., 2006. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. European Journal of Immunology 36(6) pp. 1465-1473. [DOI] [Web of Science] [Pubmed]
2005
Arinola O.G., Louis J.S., Tacchini-Cottier F., Aseffa A., Salimonu L.S., 2005. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection. African Journal of Medicine and Medical Sciences 34(1) pp. 65-70. [Pubmed]
Kariminia A., Bourreau E., Pascalis H., Couppié P., Sainte-Marie D., Tacchini-Cottier F., Launois P., 2005. Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis. Infection and Immunity 73(9) pp. 5908-5914. [DOI] [Web of Science] [Pubmed]
2004
Arinola O.G., Louis J., Tacchini-Cottier F., Aseffa A., Salimonu L.S., 2004. Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in pregnant C57BL/6 mice infected with L. major at different gestational periods. West African Journal of Medicine 23(3) pp. 202-207. [Pubmed]
Guler R., Olleros M.L., Vesin D., Parapanov R., Vesin C., Kantengwa S., Rubbia-Brandt L., Mensi N., Angelillo-Scherrer A., Martinez-Soria E. et al., 2004. Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins. Journal of Hepatology 41(5) pp. 773-781. [DOI] [Web of Science] [Pubmed]
Tacchini-Cottier F., Allenbach C., Otten L.A., Radtke F., 2004. Notch1 expression on T cells is not required for CD4+ T helper differentiation. European Journal of Immunology 34(6) pp. 1588-1596. [DOI] [Web of Science] [Pubmed]
2003
Launois P., Voigt H., Gumy A., Aseffa A., Tacchini-Cottier F., Röcken M., Louis J.A., 2003. Parasitic diseases, with an emphasis on experimental cutaneous Leishmaniasis. pp. 165-177 in Bloom B.R., Lambert P.H. (eds.) The Vaccine Book. Academic Press, San Diego. [DOI]
Otten L.A., Tacchini-Cottier F., Lohoff M., Annunziato F., Cosmi L., Scarpellino L., Louis J., Steimle V., Reith W., Acha-Orbea H., 2003. Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes. Journal of Immunology 170(3) pp. 1150-1157. [Web of Science] [Pubmed]
2002
Aseffa A., Gumy A., Launois P., MacDonald H.R., Louis J.A., Tacchini-Cottier F., 2002. The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells. Journal of Immunology 169(6) pp. 3232-3241. [Web of Science] [Pubmed]
Ferrero I., Held W., Wilson A., Tacchini-Cottier F., Radtke F., MacDonald H.R., 2002. Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage. Blood 100(8) pp. 2852-2857. [DOI] [Web of Science] [Pubmed]
2000
Himmelrich H., Launois P., Maillard I., Biedermann T., Tacchini-Cottier F., Locksley R.M., Röcken M., Louis J.A., 2000. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. Journal of Immunology 164(9) pp. 4819-4825. [Web of Science] [Pubmed]
Piguet P.F., Da Laperrousaz C., Vesin C., Tacchini-Cottier F., Senaldi G., Grau G.E., 2000. Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice. Infection and Immunity 68(7) pp. 3822-3829. [DOI] [Web of Science] [Pubmed]
Tacchini-Cottier F., Zweifel C., Belkaid Y., Mukankundiye C., Vasei M., Launois P., Milon G., Louis J.A., 2000. An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major. Journal of Immunology 165(5) pp. 2628-2636. [Web of Science] [Pubmed]
1999
Himmelrich H., Launois P., Tacchini-Cottier F., Louis J.A., 1999. Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice. Biological Chemistry 380(7-8) pp. 909-914. [DOI] [Web of Science] [Pubmed]
Launois P., Himmelrich H., Tacchini-Cottier F., Milon G., Louis J.A., 1999. New insight into the mechanisms underlying Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Microbes and Infection 1(1) pp. 59-64. [DOI] [Web of Science] [Pubmed]
Lucas R., Tacchini-Cottier F., Guler R., Vesin D., Jemelin S., Olleros M.L., Marchal G., Browning J.L., Vassalli P., Garcia I., 1999. A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection. European Journal of Immunology 29(12) pp. 4002-4010. [DOI] [Web of Science] [Pubmed]
Piguet P.F., Vesin C., Donati Y., Tacchini-Cottier F., Belin D., Barazzone C., 1999. Urokinase receptor (uPAR, CD87) is a platelet receptor important for kinetics and TNF-induced endothelial adhesion in mice. Circulation 99(25) pp. 3315-3321. [Web of Science] [Pubmed]
1998
Launois P., Conceiçao-Silva F., Himmerlich H., Parra-Lopez C., Tacchini-Cottier F., Louis J.A., 1998. Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major. Parasite Immunology 20(5) pp. 223-230. [DOI] [Web of Science] [Pubmed]
Launois P., Tacchini-Cottier F., Parra-Lopez C., Louis J.A., 1998. Cytokines in parasitic diseases: the example of cutaneous leishmaniasis. International Reviews of Immunology 17(1-4) pp. 157-180. [Pubmed]
Louis J., Himmelrich H., Parra-Lopez C., Tacchini-Cottier F., Launois P., 1998. Regulation of protective immunity against Leishmania major in mice. Current Opinion in Immunology 10(4) pp. 459-464. [DOI] [Web of Science] [Pubmed]
Louis J.A., Conceiçao-Silva F., Himmelrich H., Tacchini-Cottier F., Launois P., 1998. Anti-leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Advances in Experimental Medicine and Biology 452 pp. 53-60. [Web of Science] [Pubmed]
Tacchini-Cottier F., Vesin C., Redard M., Buurman W., Piguet P.F., 1998. Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. Journal of Immunology 160(12) pp. 6182-6186. [Web of Science] [Pubmed]
1997
Mariéthoz E., Jacquier-Sarlin M.R., Multhoff G., Healy A.M., Tacchini-Cottier F., Polla B.S., 1997. Heat shock and proinflammatory stressors induce differential localization of heat shock proteins in human monocytes. Inflammation 21(6) pp. 629-642. [DOI] [Web of Science] [Pubmed]
Sabapathy K.T., Pepper M.S., Kiefer F., Möhle-Steinlein U., Tacchini-Cottier F., Fetka I., Breier G., Risau W., Carmeliet P., Montesano R. et al., 1997. Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system. Journal of Cell Biology 137(4) pp. 953-963. [DOI] [Web of Science] [Pubmed]
1996
Barazzone C., Tacchini-Cottier F., Vesin C., Rochat A.F., Piguet P.F., 1996. Hyperoxia induces platelet activation and lung sequestration: an event dependent on tumor necrosis factor-alpha and CD11a. American Journal of Respiratory Cell and Molecular Biology 15(1) pp. 107-114. [Web of Science] [Pubmed]
Philippeaux M.M., Vesin C., Tacchini-Cottier F., Piguet P.F., 1996. Activated human platelets express beta2 integrin. European Journal of Haematology 56(3) pp. 130-137. [Web of Science] [Pubmed]
1995
Piguet P.F., Tacchini-Cottier F., Vesin C., 1995. Administration of anti-TNF-alpha or anti-CD11a antibodies to normal adult mice decreases lung and bone collagen content: evidence for an effect on platelet consumption. American Journal of Respiratory Cell and Molecular Biology 12(2) pp. 227-231. [Web of Science] [Pubmed]
Tacchini-Cottier F., Lou J.N., Roberts D.J., Garcia A.M., Grau G.E., 1995. Detection of a LFA-1-like epitope on the surface of erythrocytes infected with a strain of Plasmodium falciparum. Immunology 85(2) pp. 205-213. [Web of Science] [Pubmed]
Tacchini-Cottier F., Mayer W.E., Begovich A.B., Jones P.P., 1995. Inactivation of E alpha and E beta expression in inbred and wild mice by multiple distinct mutations, some of which predate speciation within Mus species. International Immunology 7(9) pp. 1459-1471. [DOI] [Web of Science] [Pubmed]
1994
Mariéthoz E., Tacchini-Cottier F., Jacquier-Sarlin M., Sinclair F., Polla B.S., 1994. Exposure of monocytes to heat shock does not increase class II expression but modulates antigen-dependent T cell responses. International Immunology 6(6) pp. 925-930. [DOI] [Web of Science] [Pubmed]
Qazi M.A., Senaldi G., Tacchini-Cottier F., Qazi M.H., Fayyaz-ud-Din D.C., Hoessli D.C., Walker-Nasir E., Nasir-ud-Din, 1994. Galactose residues in Plasmodium falciparum glycoproteins: incorporation and elimination. Biochemical Society Transactions 22(3) pp. 362S. [Web of Science] [Pubmed]
Tacchini-Cottier F., Grau G.E., 1994. Cytokines et paludisme. Médecine Tropicale 54(3) pp. 257-262. [Pubmed]
1993
Grau G.E., Tacchini-Cottier F., Vesin C., Milon G., Lou J.N., Piguet P.F., Juillard P., 1993. TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1 interaction. European Cytokine Network 4(6) pp. 415-419. [Web of Science] [Pubmed]
Piguet P.F., Vesin C., Ryser J.E., Senaldi G., Grau G.E., Tacchini-Cottier F., 1993. An effector role for platelets in systemic and local lipopolysaccharide-induced toxicity in mice, mediated by a CD11a- and CD54-dependent interaction with endothelium. Infection and Immunity 61(10) pp. 4182-4187. [Web of Science] [Pubmed]
1992
Grau G.E., Tacchini-Cottier F., Piguet P.F., 1992. Toxoplasmic encephalitis. Parasitology Today 8(11) p. 367. [DOI] [Web of Science] [Pubmed]
1990
Jones P.P., Begovich A.B., Tacchini-Cottier F.M., Vu T.H., 1990. Evolution of class II genes: role of selection in both the maintenance of polymorphism and the retention of non-expressed alleles. Immunologic Research 9(3) pp. 200-211. [DOI] [Web of Science] [Pubmed]
1989
Vu T.H., Begovich A.B., Tacchini-Cottier F.M., Jones P.P., 1989. Molecular defects in the non-expressed H-2 E alpha genes of the f and q haplotypes. Journal of Immunology 142(8) pp. 2936-2942. [Web of Science] [Pubmed]
1988
Tacchini-Cottier F.M., Jones P.P., 1988. Defective E beta expression in three mouse H-2 haplotypes results from aberrant RNA splicing. Journal of Immunology 141(10) pp. 3647-3653. [Web of Science] [Pubmed]
Vu T.H., Tacchini-Cottier F.M., Day C.E., Begovich A.B., Jones P.P., 1988. Molecular basis for the defective expression of the mouse Ew17 beta gene. Journal of Immunology 141(10) pp. 3654-3661. [Web of Science] [Pubmed]
Phd thesis
Coutaz M., 2015. The role of Notch receptor signaling in T helper 17 cell differentiation. 198 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier F. (dir.).
Schuster S., 2013. The role of neutrophils upon leishmania major infection. 161 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier, F. (dir.). [embargo 28/07/2016]
Zeleke T. A., 2013. Arginase as a marker of disease severity in human leishmaniasis. 127 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier F. (dir.).
Auderset F., 2012. The role of Notch receptors in T helper differentiation. 168 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier, F. (dir.).
Bottinelli D., 2012. Evaluation of the early changes occurring in the draining lymph node upon subcutaneous stimulation. 103 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier, F. (dir.).
Chakour R., 2011. Implication of TNF family members in the immune response to the infection with the intracellular protozoan parasite "Leishmania major". 95 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier F. (dir.).
Faivre-Charmoy M., 2010. Role of neutrophils in "Leishmania" infection. Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier F. (dir.).
Allenbach C., 2007. Neutrophils and TNF: two key players in the immune response induced by "Leishmania major" infection. 170 p., Université de Lausanne, Faculté de biologie et médecine, Tacchini-Cottier F. (dir.).
 
 
 
 
 
 
 
Person Position Contact
Marc Descatoire Postdoctoral fellow Unisciences
Manuel Coutaz Ph.D student Unisciences
Benjamin Hurrell Ph.D student Unisciences
Ivo Regli MD-Ph.D student Unisciences
Manon Beaumann Masters student
Yazmin Hauyon Technician Unisciences
Jess Coca Apprentice Unisciences
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Contact

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Fabienne Tacchini-Cottier

Fabienne.Tacchini-Cottier@unil.ch

Tel:       41 21 692 5703

Lab Tel: 41 21 692 5711

Fax no:  41 21 692 5705

Address: Quartier UNIL-Epalinges
              Ch. des Boveresses 155
              Office : D303
              CP 51
              CH-1066 Epalinges

Map to Office D303, Fabienne Tacchini-Cottier

Administrative Assitant

Françoise Flejszman

Tel: + 41 21 692 5735

francoise.flejszman@unil.ch

Chemin des Boveresses 155 - CH-1066 Epalinges  - Switzerland  -  Tel. +41 21 692 5700  -  Fax +41 21 692 5705
Swiss University