Published on 17.11.23
Emergence of stem-like and killer T cells in response to viral infection
The paper addresses the long-standing question of how rare naïve T cells yield a large pool of short-lived killer T cells and a minor population of long-lived stem cell-like memory T cells. The initial encounter of naïve T cells with antigen is shown to yield stem-like T cells, which by default become memory cells, but can deviate towards killer cells in response to inflammation.