Archives 2013

 

06 December 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Johannes Gräff, BMI-EPFL, Lausanne

 "Learning to forget: Using epigenetic memory aids to overcome traumatic memories"

Rememberances of traumata range among the most enduring forms of memories resulting in an elevated prevalance of anxiety disorders. In our latest research, we found a new approach on how to overcome particularly resilient traumatic memories, namely by reinstating chromatin-templated neuroplasticity in learning-related regions of the brain.

 

15 November 2013


 

Human Brain Seminar cancelled - LREN PIs giving a neuroimaging course in Poland

 

22 November 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Alexandre Reymond, CIG-UNIL, Lausanne

 "Genome structure, gene expression and neuropsychiatric disorders"

Hemizygosity of the 16p11.2 ~600 kb BP4-BP5 region (29.5 to 30.1Mb) is one of the most frequent known genetic etiology of autism spectrum disorder (ASD). It is also associated with a highly penetrant form of obesity and a significant increase in head circumference. Mirror phenotypes are observed in carriers of the reciprocal duplication, who present a high risk of being underweight, microcephalic and/or schizophrenic.

 

29 November 2013


 

Human Brain Seminar cancelled - Lausanne SPM course

 

08 November 2013


Project presentation

"Predicting long-term language function recovery after stroke"
Sandrine Muller, Patrik Michel, Bogdan Draganski, Ashraf Eskandari, Suzette D’Ambrogio-Remillard, Laurence Schneider, Valerie Beaud, Alexandre Croquelois, Jörg Kleeberg, Ferath Kherif

"Integration and segregation of motor, associative and limbic function in basal ganglia"
Renaud Marquis,Ferath Kherif, Kerstin Preuschoff, Francois Vingerhoets, Christian Wider, David Benninger, Antoine Lutti, Bogdan Draganski

 

Presentation type: Science (hosted by Bogdan Draganski)

Fabrizio Pizzagalli, Medical Genetics-CHUV, LREN - DNC, Lausanne

 "How important is accurate data pre-processing in fMRI?"

 

1 November 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Richard Benton, CIG-UNIL, Lausanne

 "Chemosensory perception and evolution in minibrains"

 

25 October 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Basic neuroscience meets clinical neuroscience (hosted by Ferath Kherif)

José Haba Rubio, Centre for Investigation and Research in Sleep (CIRS), CHUV Lausanne

 "Memory function of sleep"

 

11 October 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Ron Stoop, Laboratory on Research on the Neurobiology of Anxiety, Centre for Psychiatric Neurosciences - Cery, CHUV

 "Neuromodulation by Oxytocin and Vasopressin in the Amygdala: an optogenetic and electrophysiological dissection of the underlying circuitry"

Oxytocin and vasopressin are sister nonapeptides that have emerged from a common ancestor peptide and that differ only in two amino acids. They have appeared early in evolution and they exert different, at times opposite functions through distinct, specific receptors. In the rat brain, oxytocin and vasopressin receptors are expressed in separate regions with, in certain instances, remarkable complementary expression patterns. In the central amygdala oxytocin and vasopressin receptors are adjacently expressed in resp. the lateral (CeL) and medial part (CeM). In the CeL, we have found that oxytocin excites interneurons with inhibitory projections onto neurons in the CeM that are, in turn, excited by vasopressin. Accordingly, their effects on fear behavior are strikingly opposite. In my talk I will take this particular circuit as a potential starting point or, alternatively as a culminating endpoint, from which to consider a number of antagonistic effects of these neuropeptides on various types of behavior.

 

04 October 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Ferath Kherif)

Mohammadi Gelareh, EPFL Lausanne

"The Voice of Personality"

Whenever we listen to a voice for the first time, we attribute personality traits to the speaker. The perception process takes place in a
few seconds and it is spontaneous and unaware. While the process is not necessarily accurate still it influences significantly our behavior towards others, especially when it comes to social interaction. This talk is about an approach for the automatic prediction of the traits the listeners attribute to a speaker they never heard before.

 

27 September 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Ferath Kherif)

Jürgen Dukart, LREN

 

20 September 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Kerstin Preuschof)

Joerg Hipp, University Tübingen, Germany

 "Large-scale neuronal interactions in the human brain"

I will talk about electrophysiological signatures of large-scale neuronal interaction derived non-invasively from EEG and MEG in humans.In particular, I’ll talk about the transient formation of networks of synchronized neuronal activity underlying specific cognitive processes. Furthermore, I’ll talk about an electrophysiological counterpart of the well-known 'fMRI resting state connectivity', and highlight our methodological advances that were prerequisite for studying electrophysiological connectivity in the 'resting state'.

Besides new work I will present results from these two papers:
http://www.cell.com/neuron/abstract/S0896-6273%2810%2901075-5
http://www.nature.com/neuro/journal/v15/n6/full/nn.3101.html

28 June 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Micah Murray)

Luca Cocchi, Queensland Brain Institute, University of Queensland - Brisbane, Australia

 "Modulation of large-scale neural networks by local TMS"

 

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that can induce transitory alterations of brain activity via the application of a rapidly changing focal magnetic field. TMS has been touted as a possible treatment for a number of neurological and psychiatric disorders. These clinical applications are motivated by the hypothesis that changes in local brain activity induced by TMS can restore the function of large-scale brain networks affected by the disorders. Such widespread effects of TMS remain, however, hypothetical. In this talk I am going to present and discuss original data from a study investigating the reconfiguration of functional brain networks following changes in local cortical excitability induced by TMS.

 

 

21 June 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Clinical neuroscience meets basic neuroscience (hosted by Bogdan Draganski)

Patrik Michel, DNC-CHUV, Lausanne

 "The Acute STroke Registry and Analysis of Lausanne (ASTRAL) : an opportunity to connect clinics, neuroimages and more ... "

 

14 June 2013


Project presentation

No project presentation scheduled. 

 

Presentation type: Science (hosted by Bogdan Draganski)

Michael Herzog, Laboratory of Psychophysics, BMI - EPFL

 "A vision into madness"

 

 

07 June 2013


Project presentation

No Project presentation scheduled

 

Presentation type: Science (hosted by Ferath Kherif)

Carl Petersen, BMI-EPFL, Lausanne

"Functional mapping of the mouse sensorimotor cortex"

 

31 Mai 2013


Project presentation

No Project presentation scheduled

 

Presentation type: Science (hosted by Melissa Saenz)

Wietske vd Zwaag, CIBM-EPFL, Lausanne

"Functional MRI at 7 Tesla – beyond blobs"

Use of ultra-high field scanners (>3T) brings several advantages to functional MRI, foremost a stronger BOLD signal and the possibility of acquiring very high resolution, even sub-millimeter, images. However, there are also several factors which have to be considered carefully in order to make a 7T fMRI study a success. In this presentation, I will discuss the advantages, disadvantages and some solutions for ultra-high field fMRI, before showing how these have been applied in several neuroimaging studies.

 

24 Mai 2013


Project presentation

No Project presentation scheduled

 

Presentation type: Science (hosted by Bogdan Draganski)

Patrick Fraering, Laboratory of Molecular and Cellular Biology of Alzheimer's Disease, BMI - EPFL

"Modulation of Gamma-secretase for the treatment of Alzheimer’s disease: strategies and promises"

Topic: Gamma-secretase inhibitors tested in clinical trials for Alzheimer’s disease manifested severe off-target effects mainly attributed to impaired Notch signaling. In my talk, I will describe the concept of APP selective modulation of gamma-secretase and its promises for safely treating this neurological disorder.

 

17 Mai 2013


Project presentation

no Project presentation this week

 

Presentation type: Science (hosted by Bogdan Draganski)

Renaud du Pasquier, Neuroimmunology laboratory, DNC - CHUV, Lausanne

  "Synergies between neuroimmunology and brain imaging - what can we do together?"

tba

 

10 Mai 2013


 

HOLIDAYS

 

03 Mai 2013


Project presentation

no Project presentation this week

 

Presentation type: Science (hosted by Ferath Kherif)

Varun Sharma & Kerstin Preuschoff

  "Accurately measuring risky behavior through adaptive sampling"

 

 

19 April 2013


Project presentation

No project presentation this week

 

Presentation type: Science (hosted by Bogdan Draganski)

Dr William Simpson, School of Psychology, University of Plymouth - UK

  "Analysis of fNIRS data with the kernel Distributed Lag Model"

I will describe a novel way to analyse functional brain imaging data, which I call the kernel Distributed Lag Model (kDLM). Conceptually it is similar to the widely-used GLM method. However, the usual way of using GLM depends on a so-called "canonical haemodynamic response function". The form of the canonical HRF is assumed. That is a problem, because your data may be coming from an HRF that is different from what is assumed. The true HRF may have a different delay or shape. That means you may fail to detect a real effect of your stimulus on the response, or you may think there is an effect when there really is none. In kDLM we get all the same information delivered by GLM, plus we estimate the HRF at the same time, for free. The method is very simple and robust -- it is linear regression with a twist. I will demonstrate the use of kDLM with real fNIRS data.

 

 22 March 2013


Project presentation

No project presentation this week.

 

Presentation type: Mid-term evaluation talks (hosted by Antoine Lutti)

Anne Ruef - LREN, DNC - CHUV, Lausanne

"Brain anatomy patterns as endophenotypes of mood disorders"

Valerie Zufferey - LREN, DNC - CHUV, Lausanne

"Inter-individual differences in anatomo-functional brain networks related to memory and personality in early Alzheimer’s disease and healthy controls"

 

15 March 2013


Project presentation

No project presentation this week.

 

Presentation type: Science (hosted by Melissa Saenz)

Liliane Tenenbaum, DNC - CHUV, Lausanne

 "Towards a clinically acceptable regulatable viral vector for neurotrophic factor gene delivery for Parkinson’s disease"

Viral vectors incorporating drug-dependent genetic switches have demonstrated control of therapeutical and undesirable effects of transgenes in preclinical models.Challenges to reach clinical use are immune responses to the proteic components of the genetic switch, toxicity of the drug inducer and monitoring of the effects of the therapeutic transgene in patients.

 

08 March 2013


Project presentation

no Project presentation this week

 

Presentation type: Science (hosted by Bogdan Draganski)

Jürgen Dukart, LREN - DNC, CHUV, Lausanne

 "Electro-Convulsive Therapy Induced Brain Plasticity Determines Therapeutic Outcome in Mood Disorders"

I will present recent findings of brain structure changes after application of electro-convulsive therapy in patients with unipolar depression and bipolar disorder. I will discuss the potential implications for future research and novel therapeutic strategies.

 

 

01 March 2013


Project presentation

No project presentation this week.

 

Presentation type: Distinguished speaker series (hosted by Bogdan Draganski)

Nicolas Toni, Département des neurosciences fondamentales, FBM UNIL

  "Adult hippocampal neurogenesis: Is more the better ?"

It is now accepted that the adult mammalian brain retains stem cells with neurogenic potential. The questions remain: what is the function of adult neurogenesis, how is it regulated and can we use it to our advantage?

 

22 February 2013


Project presentation

No Project presentation this week.

 

Presentation type: Science (hosted by Cristina Granziera)

David Romascano, CIBM-EPFL, Lausanne

  "Structural and functional connectivity of the cerebellum in Multiple Sclerosis"

I will present our findings on cerebellar connectivity differences between Multiple Sclerosis (MS) patients and healthy controls using Diffusion Spectrum Imaging (DSI) and resting-state fMRI.

 

15 February 2013


Project presentation

No Project presentation this week

 

Presentation type: Science (hosted by Bogdan Draganski)

Nicole Deglon, Laboratory of Cellular and Molecular Neurotherapies, DNC CHUV, Lausanne

  "Added value of molecular and cellular strategies for neurodegenerative diseases?"

In my talk I will focus on description of the know-how and tools which are available in the "wet LCMN lab" and how to integrate/collaborate with clinicians.

 

08 February 2013


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Sebastien Jacquemont, Medical Genetics, CHUV UNIL

 "Rare genetic variants in common neuropsychiatric disorders. The 16p11.2 rearrangement"

 

 

01 February 2013


Project presentation

tba

"tba"

tba. 

 

Presentation type: Science  (hosted by Ferath Kherif)

Fiona Hollis, Lab of Behavioural Genetics (Carmen Sandi's lab), EPFL

  "The effect of anxiety on the perception of dominance"

We are interested in examining how trait anxiety might modulate the response to dominance with respect to behavior and BOLD signal in the ventral striatum. We will present pilot data from our behavioral task and discuss how to best modify this task for the scanner.

 

25 January 2013


Project presentation

tba

"tba"

tba. 

 

Presentation type: Science (hosted by Melissa Saenz & Micah Murray)

Evelin Geiser, McGovern Institute for Brain Research, MIT Boston, USA

  "Making sense of the acoustic environment: Neural mechanisms of global timing perception"

Timing perception is an inherent feature of all sensory experience. Without its underlying temporal structure, perception would be unthinkable. To efficiently perceive and interact with our environment, we rely on both temporal regularities and temporal grouping structures. The processing of these two kinds of temporal patterns – referred to as global timing - is a fundamental capacity of the human brain. Recent experimental evidence on perceptual, neural, and neuro-chemical mechanisms involved in global timing perception will be presented.

 

18 January 2013


Project presentation

No project presentation scheduled

 

Presentation type: Science (hosted by Bogdan Draganski)

Richard Camicioli, Neurology, University of Alberta, Canada

  "Structural imaging in Parkinson´s disease - why bother?"

I will provide a brief introduction to aspects of the semiology of Parkinson's disase (PD) for scientists - highlighting the importance of non-motor aspects. In addition I will discuss the basis for dementia and imaging changes associated with dementia with an emphasis on structural MRI, as an example of one critical non-motor aspect of PD.

 

11 January 2013


Project presentation

no project presentation scheduled

 

Presentation type: Clinical neuroscience meets basic science (hosted by Bogdan Draganski)

Andrea Rossetti, Department des neurosciences cliniques - Neurologie, CHUV

  "Prediction of clinical outcome after cardiac arrest - the neurological perspective"

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