Archives 2014


 

19 December 2014


Presentation type: Science (hosted by Antoine Lutti)

Patric Hagmann, Radiology, University of Lausanne, Switzerland

Title: "An update on MR connectomics : psychosis and other things"

 

11 December 2014


Presentation type: Science (hosted by Bogdan Draganski)

Daniel Alexander, Department of Computer Science, UCL London UK

Title: "Novel techniques for diffusion weighted imaging data analysis"

 

28 November 2014


Projects Presentation 3.30pm-4pm

Applicants: Leyla Loued-Khenissi

Title: "Study of the Mechanisms Behind Perceptual Uncertainty Using a Rivalry Paradigm"

 

Applicants: Vasiliki Liakoni

Title: "Reinforcement Learning and Sequential Decision Making"  

 

Presentation type: Science (hosted by Ferath Kherif) 4pm-5pm

Zoltan Kutalik, Institute of Social and Preventive Medicine - CHUV, University of Lausanne, Switzerland

Title: "Tackling obesity genetics from multiple angles"

 

21 November 2014


Human Brain Seminar cancelled due to LRENs SPM course

 

 

7 November 2014


Presentation type: Science (hosted by Bogdan Draganski)

 

Frank Scharnowski, Radiology-CIBM, University of Geneva, Switzerland

Title: "Neurofeedback based on real-time fMRI"

Outline: The talk will describe new neurofeedback approaches based on real-time fMRI, and how they can be used to study cause-and-effect relationships in cognitive neuroscience, and to normalize dysfunctional brain areas/networks in psychiatric and neurological disorders.

 

 

 

31 October 2014


Presentation type: Science (hosted by Antoine Lutti)

Daniel Gallichan, DPhil, Centre d'Imagerie BioMédicale (CIBM)

Title: "High-resolution motion-correction in Magnetic Resonance Imaging"

Outline: As MR images are pushed to higher spatial resolutions, so they become more sensitive to unavoidable small movements of the subject, even in healthy volunteers. I will present initial results using highly-accelerated fat images acquired interleaved with the main acquisition in order to track, and correct for, these small movements. Image quality is noticeably improved, even for very small head movements.

 

24 October 2014


Project presentation

Co-applicants: Christian Lambert, Ferath Kherif, Antoine Lutti & Bogdan Draganski

Title: "High-resolution multi-parameter mapping of brain tissue properties in Parkinson's Disease"

 

Presentation type: Science (hosted by Antoine Lutti)

Christian Lambert, St George'e University Hospital London, UK

Title: "Challenges and Developments in Multimodal Quantitative Computational Anatomy"

Outline: In this talk, I shall outline previous advances with multi-parameter mapping and advanced quantitative segmentation of the human brainstem and cortex. I will discuss the problems pathological brain tissue poses to current methodological frameworks that have been developed using healthy controls, and highlight these issues using a longitudinal dataset of patients with small vessel disease. Additionally, I will introduce recent collaberative work examining “anomalous diffusion” (aDTI), a technique that utilises a continuous random time walk model to accurately parameterise the diffusion curve, providing insights into tissue microstructural properties beyond fractional anisotropy. I will demonstrate some of the biophysical properties of the quantitative aDTI parameters using the Human Connectome Project dataset. Finally, I will use a variety of metrics to discuss one of the problems associated with multimodal segmentation, namely the variability in clustering solutions that can be extracted from a single structure, and outline on-going work attempting to reconcile these observed differences.

 

 

17 October 2014


Presentation type: Science (hosted by Bogdan Draganski)

Jacques Beckmann, Swiss Institute of Bioinformatics, Lausanne

Title: "The microbiome: Impact on Health and Disease"

 

 

3 October 2014

 


Project presentation

 

Jean-François Démonet, M.D., Ph.D, Memory Center Director, Department of Clinical Neuroscience, CHUV

"MargaretRoad: a study of anti-amyloid immunotherapy in early Alzheimer's disease"

 

 

12 September 2014

 


Presentation type: Science (hosted by Ferath Kherif)

 

Pascal Savary, jurist, Affaire Juridiques, CHUV

 

"Legal aspects of the human research."

 

"The new Federal act of 30 September 2011 introduced changes in practical aspects on Research involving Human Beings (Human Research Act, or HRA) from January first 2014. In particular, there are new procedures applicable for the Ethical commission, respectively Swissmedic, documents to be provided and distinction  to be made between clinical trials and research without patients. Different consents shall also be obtained from the subjects/patients depending of the research qualification.”

 

5 September 2014

 


Project presentation

 

Jean-François Démonet, M.D., Ph.D, Memory Center Director, Department of Clinical Neuroscience, CHUV

 

"MEM-NEURO: the brain imaging project of CLM"

 

Presentation type: Science (hosted by Marzia De Lucia)

 

Francesca Siclari, MD, Centre d'investigation et de recherche sur le sommeil, CHUV; Department of Psychiatry, University of Wisconsin, Madison

"The neural correlates of consciousness in sleep: a high-density EEG study"

 

15 August 2014

 


Project presentation

 

Laura Cif, DNC, LREN, CHUV



"Neuro-biological model of obsessive compulsive disorders: identification of endo-phenotypes."

 

 

4 July 2014

 


Project presentation

 

Loued-Khenissi Leyla, Kerstin Preuschoff, Brain Mind Institute Laboratory of Behavioral Genetics – LGC EPFL and LREN, Department of Clinical Neurosciences, CHUV

 

"Imaging the question mark: an investigation of pupillary and BOLD responses to uncertainty in a gambling task"

 

Presentation type: Science (hosted by Bogdan Draganski)

 

Fatnassi Chemseddine, Departement de radio-oncologie, Clinique Bois-Cerf, Hirslanden

 

"Non Linear Phase Model for Correction of Magnetic Field Inhomogeneity Effects in 3D Quantitative Gradient Echo Based MRI."

"R2* plays an important role in the quantitative evaluation of the brain function and tissue iron content. Unfortunately, susceptibility induced macroscopic field inhomogeneities (B0 macro) across an image voxel act to increase the R2* in a gradient echo image. If these B0macro are measurable their influence can be removed in post processing. Conventionally, these algorithms assume the phase evolves linearly with time; however, in the presence of a large B0macro, e.g. near the edge of the brain, this is assumption is broken. The phase evolution appears random. herein, we hypothesize that the phase evolution in the presence of large B0macro, can be modeled and corrected using 1D-random-walk theory. "

 

 

 

 

27 June 2014

 


Project presentation

 

Lara Bontadelli, Valérie Zufferey, Bogdan Draganski, Elisabeth Roggenhofer, Ferath Kherif, LREN, Department of Clinical Neurosciences, CHUV

 

"Probabilistic learning fMRI task and dysphoria"

 

  

Presentation type: Science (hosted by Bogdan Draganski)

 

Camilla Bellone, Department of Fundamental Neurosciences, University of Lausanne

 

"Postnatal development of excitatory transmission in the VTA."

"Postnatal periods of development are characterized by rapid changes in neuronal networks, providing critical periods in which environmental experience can lead to long-term changes in brain and behaviour. In the Ventral Tegmental Area (VTA), postnatal maturation of excitatory transmission is regulated by mGluR1, which orchestrates both the subunit composition of AMPARs and NMDARs. We investigated the molecular mechanisms underlying mGluR1 activation and found that selective manipulation of a gene associated with Autism Spectrum Disorders (ASDs) in the VTA leads to an incomplete postnatal maturation of excitatory transmission in the VTA suggesting that VTA may be implicated in some of the behavioural symptoms observed in ASDs."

 

 

 

 

16 May 2014

 


 Project presentation

Sandra Martin, Sebastien Jacquemont, Anne Maillard, Bogdan Draganski

 "MRI Study in patients with deletions or duplications of the 16p11.2 region"

  

Presentation type: Science (hosted by Bogdan Draganski)

 

Gunther Helms, Lund University, Sweden

 

"Special Brains-Genius,Disease,Madness"


 

 

09 May 2014

 


 Project presentation

 No project presentation scheduled.

  

Presentation type: Science (hosted by Melissan Saenz)

Prof Dimitri Van de Ville, EPFL/UniGe

 

"Restless at rest: dynamic functional connectivity as a new measure to probe brain network organization"

Functional connectivity (FC) as extracted from fMRI data has become a key measure to study the brain's functional integration. FC is obtained as the correlation between timecourses of different voxels or brain regions, conventionally computed for the full duration of the resting-state scanning session. Recently, temporal variations in FC have been observed using sliding-window correlation, for which the term dynamic functional connectivity (dynFC) has been coined. Despite the risk of spurious fluctuations due to short window length, we reported meaningful dynFC that reflected complementary information w.r.t. standard FC. We recently proposed a multivariate framework to facilitate the analysis and interpretation of dynFC in terms of FC building blocks. We also showed clinical relevance of dynFC; e.g., resting-state fluctuations of FC allow to discriminate healthy controls from minimally-disabled MS patients.

N. Leonardi, J. Richiardi, M. Gschwind, S. Simoni, J.-M. Annoni, M. Schluep, P. Vuilleumier, D. Van De Ville, Principal Components of Functional Connectivity: A New Approach to Study Dynamic Brain Connectivity During Rest, NeuroImage, vol. 83, pp. 937-95, 2013.

 

 

 

02 May 2014

 


 Project presentation

 No project presentation scheduled.

  

Presentation type: Science (hosted by Sandrine Muller)

 

Dr. Jean-François Brunet CHUV

 

"From research in cell therapy in neuroscience to production of ATMP"
 

 

11 April 2014

 


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Diana Khabipova and  Mayur Narsude, CIBM, EPFL, Lausanne.

 

"Modulated closed form solution for quantitative susceptibility mapping"

and

" Whole brain fMRI in 370ms: exploring the benefits of high temporal resolution 3D-EPI-CAIPI"

  

 

 

04 April 2014

 


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Bogdan Draganski)

Dominik Bach, Comparative Emotion Group, Zurich University Hospital for Psychiatry
 

"Cross-species models of defensive emotions"

 

  

 

28 March 2014 


Project presentation

 No project presentation scheduled.

  

Presentation type: Science (hosted by Bogdan Draganski)

Raffaella Torrisi, Child and Adolescents Psychiatry, CHUV Lausanne

"Stress and oxytocin responses in adults exposed to traumatic events"

 

 

21 March 2014 


Project presentation

No project presentation scheduled.

 

 Presentation type: Science (hosted by Bogdan Draganski)

Jacques Besson, Department of Psychiatry, CHUV Lausanne

"Spirituality and addiction"

 

 

14 March 2014


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Lorenz Hirt)

Andre Obenaus, PhD, Loma Linda University, California, USA

"Do repetitive mild traumatic brain injuries result in worse outcomes?"

 

 

7 March 2014


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Domenica Buetti)

Masamichi Hayashi, PhD, University of Sussex, UK

"Neural representation of time intervals in humans."

  

Precise estimation of time interval is crucial for our perception and behavior. Several theoretical models of time perception have predicted that elapsed time is explicitly represented by a population of neurons that fire selectively for their preferred durations, however, the empirical evidence has been missing. In this talk, I will describe my recent fMRI study that provides evidence of explicit duration representations in the human brain.

 

 

28 February 2014


Project presentation

No project presentation scheduled.

 

Presentation type:

No presentation scheduled.

  

 

21 February 2014


Project presentation

No project presentation scheduled.

 

 

 

Presentation type: Science (hosted by Bogdan Draganski)

 

Cristina Granziera, DNC - CHUV & EPFL.
"Imaging the ultrastructural organization of the cerebellum"

 

 

 

 

 

14 February 2014

 


 

Project presentation

 

No project presentation scheduled.

 

 

 

 

 

 

 

Presentation type: Science (hosted by Bogdan Draganski)

 

Jacques Beckmann, Head of Clinical Bioinformatics at SIB Swiss Institute of Bioinformatics.
"The microbiome: impact on health and diseases, including brain diseases"

 

 

 

 

 

7 February 2014

 


 

Project presentation

 

Elisabeth Roggenhofer, Andrea Rossetti, David Slater, Antoine Lutti & Bogdan Draganski, LREN -DNC, CHUV
"Computational anatomy in focal epilepsy"

 

 

 

Presentation type: Science (hosted by Bogdan Draganski)

 

Nicolas Kunz, Scientifique Collaborator at Animal Imaging and Technology, CIBM-AIT
"Biophysical compartment diffusion models: application to the developing human brain"

 

Diffusion tensor imaging (DTI) has demonstrated its unique ability to probe cellular architecture and brain connectivity. Despite the valuable information that DTI provides about the general organization, integrity and maturation of fiber bundles, the interpretation of the changes on a cellular scale remains very challenging. Recently, new biophysical compartment diffusion model, based on the local diffusion process (such as restriction, hindrance or free diffusion), have been proposed, which make possible to relate diffusion-weighted signals directly to the cellular structure. I will present you the basis of these new biophysical diffusion models and the application of CHARMED and NODDI to the developing human brain.

 

 

 

10 January 2014


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Richard Frackowiak)

Soren Solari, Senior Solutions Architect at Nestle Institute of Health Sciences

 "Cognitive Consilience - the blueprint of cognition through the 7 neuroanatomical circuits underlying cognitive information processing."

 

Cognitive Consilience is an attempt to form a comprehensive and cohesive understanding of the primate non-primary neuroanatomical cognitive circuitry through consilience (the integration of knowledge). The first goal is to assemble and synthesize a comprehensive accurate neuroanatomical picture correlated to basic psychological function (eg working memory, short-term memory, etc), fully referenced from hundreds of original neuroanatomy studies. Secondly we utilize web and iPad technology to produce an interactive visualization that can be explored dynamically. The talk will provide the motivation for such a daunting effort, present new integrated neuroanatomical facts with hypothesis on brain function, walk through the interactive website, and discuss the future of information integration to form comprehensive theories in science in the modern age.

  

 

24 January 2014


Project presentation

No project presentation scheduled.

 

Presentation type: Science (hosted by Ferath Kherif)

Daniel Damian, Centre Lennaards de la Memoire, DNC-CHUV, Lausanne

 "Instem's Safety Intelligence Program - an intelligence network for drug safety assessment"

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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