List of Publications
Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach. [DOI]
Strefeler A., Jan M., Quadroni M., Teav T., Rosenberg N., Chatton J.Y., Guex N., Gallart-Ayala H., Ivanisevic J., 2023/01/09. Alzheimer's research & therapy, 15 (1) p. 8. Peer-reviewed.
Immunoediting instructs tumor metabolic reprogramming to support immune evasion. [DOI]
Tsai C.H., Chuang Y.M., Li X., Yu Y.R., Tzeng S.F., Teoh S.T., Lindblad K.E., Di Matteo M., Cheng W.C., Hsueh P.C. et al., 2023/01/03. Cell metabolism, 35 (1) pp. 118-133.e7. Peer-reviewed.
A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation. [DOI]
Ince Y.Ç., Krahmer J., Fiorucci A.S., Trevisan M., Galvão V.C., Wigger L., Pradervand S., Fouillen L., Van Delft P., Genva M. et al., 2022/10/10. Nature communications, 13 (1) p. 5659. Peer-reviewed.
Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia. [DOI]
ElMokh O., Matsumoto S., Biniecka P., Bellotti A., Schaeuble K., Piacente F., Gallart-Ayala H., Ivanisevic J., Stamenkovic I., Nencioni A. et al., 2022/04/08. Cell death & disease, 13 (4) p. 320. Peer-reviewed.
The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review. [DOI]
Carrard J., Guerini C., Appenzeller-Herzog C., Infanger D., Königstein K., Streese L., Hinrichs T., Hanssen H., Gallart-Ayala H., Ivanisevic J. et al., 2022/03. Sports medicine, 52 (3) pp. 527-546. Peer-reviewed.
PERK is a critical metabolic hub for immunosuppressive function in macrophages. [DOI]
Raines L.N., Zhao H., Wang Y., Chen H.Y., Gallart-Ayala H., Hsueh P.C., Cao W., Koh Y., Alamonte-Loya A., Liu P.S. et al., 2022/03. Nature immunology, 23 (3) pp. 431-445. Peer-reviewed.
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy. [DOI]
Laurila P.P., Luan P., Wohlwend M., Zanou N., Crisol B., Imamura de Lima T., Goeminne LJE, Gallart-Ayala H., Shong M., Ivanisevic J. et al., 2022/01/28. Science advances, 8 (4) pp. eabh4423. Peer-reviewed.
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. [DOI]
Di Conza G., Tsai C.H., Gallart-Ayala H., Yu Y.R., Franco F., Zaffalon L., Xie X., Li X., Xiao Z., Raines L.N. et al., 2021/11. Nature immunology, 22 (11) pp. 1403-1415. Peer-reviewed.
Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS. [DOI]
van der Velpen V., Rosenberg N., Maillard V., Teav T., Chatton J.Y., Gallart-Ayala H., Ivanisevic J., 2021/10. Journal of neurochemistry, 159 (2) pp. 378-388. Peer-reviewed.
How Ceramides Orchestrate Cardiometabolic Health-An Ode to Physically Active Living. [DOI]
Carrard J., Gallart-Ayala H., Weber N., Colledge F., Streese L., Hanssen H., Schmied C., Ivanisevic J., Schmidt-Trucksäss A., 2021/09/30. Metabolites, 11 (10) p. 675. Peer-reviewed.
The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects. [DOI]
Tran C., Turolla L., Ballhausen D., Buros S.C., Teav T., Gallart-Ayala H., Ivanisevic J., Faouzi M., Lefeber D.J., Ivanovski I. et al., 2021/09. Molecular genetics and metabolism reports, 28 p. 100777. Peer-reviewed.
Central anorexigenic actions of bile acids are mediated by TGR5. [DOI]
Perino A., Velázquez-Villegas L.A., Bresciani N., Sun Y., Huang Q., Fénelon V.S., Castellanos-Jankiewicz A., Zizzari P., Bruschetta G., Jin S. et al., 2021/05. Nature metabolism, 3 (5) pp. 595-603. Peer-reviewed.
Metabolic View on Human Healthspan: A Lipidome-Wide Association Study. [DOI]
Carrard J., Gallart-Ayala H., Infanger D., Teav T., Wagner J., Knaier R., Colledge F., Streese L., Königstein K., Hinrichs T. et al., 2021/04/30. Metabolites, 11 (5) p. 287. Peer-reviewed.
DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies. [DOI]
Bararpour N., Gilardi F., Carmeli C., Sidibe J., Ivanisevic J., Caputo T., Augsburger M., Grabherr S., Desvergne B., Guex N. et al., 2021/03/11. Scientific reports, 11 (1) p. 5657. Peer-reviewed.
The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis. [DOI]
Carrard J., Guerini C., Appenzeller-Herzog C., Infanger D., Königstein K., Streese L., Hinrichs T., Hanssen H., Gallart-Ayala H., Ivanisevic J. et al., 2021. BMJ open sport & exercise medicine, 7 (1) pp. e001008. Peer-reviewed.
Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights. [DOI]
Gander J., Carrard J., Gallart-Ayala H., Borreggine R., Teav T., Infanger D., Colledge F., Streese L., Wagner J., Klenk C. et al., 2021. Frontiers in cardiovascular medicine, 8 p. 792350. Peer-reviewed.
Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome. [DOI]
Medina J., van der Velpen V., Teav T., Guitton Y., Gallart-Ayala H., Ivanisevic J., 2020/12/02. Metabolites, 10 (12) p. 495. Peer-reviewed.
Metabolomics meets lipidomics: Assessing the small molecule component of metabolism. [DOI]
Gallart-Ayala H., Teav T., Ivanisevic J., 2020/12. BioEssays, 42 (12) pp. e2000052. Peer-reviewed.
Warmth Prevents Bone Loss through the Gut Microbiota. [DOI]
Chevalier C., Kieser S., Çolakoğlu M., Hadadi N., Brun J., Rigo D., Suárez-Zamorano N., Spiljar M., Fabbiano S., Busse B., Ivanisevic J., Macpherson A., Bonnet N., Trajkovski M., 2020. Cell Metabolism 32:4, 575-590.
Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models. [DOI]
Hadadi N., Pandey V., Chiappino-Pepe A., Morales M., Gallart-Ayala H., Mehl F., Ivanisevic J., Sentchilo V., Meer JRV, 2020. NPJ systems biology and applications, 6 (1) p. 1. Peer-reviewed.
From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data. [DOI]
Ivanisevic J., Want E.J., 2019/12/17. Metabolites, 9 (12). Peer-reviewed.
Systemic and central nervous system metabolic alterations in Alzheimer's disease. [DOI]
van der Velpen V., Teav T., Gallart-Ayala H., Mehl F., Konz I., Clark C., Oikonomidi A., Peyratout G., Henry H., Delorenzi M. et al., 2019/11/28. Alzheimer's research & therapy, 11 (1) p. 93. Peer-reviewed.
Merged Targeted Quantification and Untargeted Profiling for Comprehensive Assessment of Acylcarnitine and Amino Acid Metabolism. [DOI]
Teav T., Gallart-Ayala H., van der Velpen V., Mehl F., Henry H., Ivanisevic J., 2019/09/17. Analytical chemistry, 91 (18) pp. 11757-11769. Peer-reviewed.
Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. [DOI]
Cianciaruso C., Beltraminelli T., Duval F., Nassiri S., Hamelin R., Mozes A., Gallart-Ayala H., Ceada Torres G., Torchia B., Ries C.H. et al., 2019/06/04. Cell reports, 27 (10) pp. 3062-3080.e11. Peer-reviewed.
Identification of bioactive metabolites using activity metabolomics. [DOI]
Rinschen M.M., Ivanisevic J., Giera M., Siuzdak G., 2019/06. Nature reviews. Molecular cell biology, 20 (6) pp. 353-367. Peer-reviewed.
Ammonium accumulation and chemokine decrease in culture media of Gcdh<sup>-/-</sup> 3D reaggregated brain cell cultures. [DOI]
Cudré-Cung H.P., Remacle N., do Vale-Pereira S., Gonzalez M., Henry H., Ivanisevic J., Schmiesing J., Mühlhausen C., Braissant O., Ballhausen D., 2019/04. Molecular genetics and metabolism, 126 (4) pp. 416-428. Peer-reviewed.
A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects. [DOI]
Gallart-Ayala H., Konz I., Mehl F., Teav T., Oikonomidi A., Peyratout G., van der Velpen V., Popp J., Ivanisevic J., 2018/12/11. Analytica chimica acta, 1037 pp. 327-337. Peer-reviewed.
LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid. [DOI]
Mehl F., Gallart-Ayala H., Konz I., Teav T., Oikonomidi A., Peyratout G., van der Velpen V., Popp J., Ivanisevic J., 2018/12. Data in brief, 21 pp. 1358-1362. Peer-reviewed.
De novo NAD<sup>+</sup> synthesis enhances mitochondrial function and improves health. [DOI]
Katsyuba E., Mottis A., Zietak M., De Franco F., van der Velpen V., Gariani K., Ryu D., Cialabrini L., Matilainen O., Liscio P. et al., 2018/11. Nature, 563 (7731) pp. 354-359. Peer-reviewed.
XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules. [DOI]
Domingo-Almenara X., Montenegro-Burke J.R., Ivanisevic J., Thomas A., Sidibé J., Teav T., Guijas C., Aisporna A.E., Rinehart D., Hoang L. et al., 2018/09. Nature methods, 15 (9) pp. 681-684. Peer-reviewed.
Autonomous Multimodal Metabolomics Data Integration for Comprehensive Pathway Analysis and Systems Biology. [DOI]
Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B. et al., 2018/07/17. Analytical chemistry, 90 (14) pp. 8396-8403. Peer-reviewed.
Metabolomics as a Tool to Understand Pathophysiological Processes. [DOI]
Ivanisevic Julijana, Thomas Aurelien, 2018. pp. 3-28 dans Methods in Molecular Biology chap. 1, Springer New York.
New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria. [DOI]
Remacle N., Forny P., Cudré-Cung H.P., Gonzalez-Melo M., Vale-Pereira S., Henry H., Teav T., Gallart-Ayala H., Braissant O., Baumgartner M. and Ballhausen D., 2018. Molecular Genetics and Metabolism, 124, 266-277.
Metabolomics: a tool to characterize the effect of phthalates and bisphenol A. [DOI]
Gómez C., Gallart-Ayala H., 2018. Environmental Reviews, 26 (4) 351-357.
Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes. [DOI]
Montenegro-Burke J.R., Aisporna A.E., Benton H.P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B.T., Ivanisevic J. et al., 2017/01/17. Analytical chemistry, 89 (2) pp. 1254-1259. Peer-reviewed.
Systems biology guided by XCMS Online metabolomics. [DOI]
Huan T., Forsberg E.M., Rinehart D., Johnson C.H., Ivanisevic J., Benton H.P., Fang M., Aisporna A., Hilmers B., Poole F.L. et al., 2017/04/27. Nature methods, 14 (5) pp. 461-462. Peer-reviewed.
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. [DOI]
Liu P.S., Wang H., Li X., Chao T., Teav T., Christen S., Di Conza G., Cheng W.C., Chou C.H., Vavakova M. et al., 2017/09. Nature immunology, 18 (9) pp. 985-994. Peer-reviewed.
Metabolic drift in the aging brain. [DOI]
Ivanisevic J., Stauch K.L., Petrascheck M., Benton H.P., Epstein A.A., Fang M., Gorantla S., Tran M., Hoang L., Kurczy M.E. et al., 2016/05. Aging, 8 (5) pp. 1000-1020. Peer-reviewed.
Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation. [DOI]
Kurczy M.E., Forsberg E.M., Thorgersen M.P., Poole F.L., Benton H.P., Ivanisevic J., Tran M.L., Wall J.D., Elias D.A., Adams M.W. et al., 2016/06/17. ACS chemical biology, 11 (6) pp. 1677-1685. Peer-reviewed.
Metabolomics: beyond biomarkers and towards mechanisms. [DOI]
Johnson C.H., Ivanisevic J., Siuzdak G., 2016/07. Nature reviews. Molecular cell biology, 17 (7) pp. 451-459. Peer-reviewed.
Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. [DOI]
Cudré-Cung H.P., Zavadakova P., do Vale-Pereira S., Remacle N., Henry H., Ivanisevic J., Tavel D., Braissant O., Ballhausen D., 2016/09. Molecular genetics and metabolism, 119 (1-2) pp. 57-67. Peer-reviewed.
Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. [DOI]
Fang M., Ivanisevic J., Benton H.P., Johnson C.H., Patti G.J., Hoang L.T., Uritboonthai W., Kurczy M.E., Siuzdak G., 2015. Analytical Chemistry, 87 (21) pp. 10935-10941. Peer-reviewed.
