RECENT PUBLICATIONS (since Platform creation in 2016 onwards)


Tran C.*, Turolla L., Ballhausen D., Cornaz Buros D., Teav T., Gallart-Ayala H., Ivanisevic J., Faouzi M., Lefeber D.J., Ivanovski I., Giangiobbe S., Caraffi G. S., Garavelli L., Superti-Furga A. The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects. Molecular Genetics and Metabolism Reports 2021, 28:100777  [DOI]

Perino A., Velázquez-Villegas L.A., Bresciani N., Sun Y., Huang Q., Fénelon V.S., Castellanos-Jankiewicz A., Zizzari P., Bruschetta G., Jin S., Baleisyte A., Gioiello A., Pellicciari R., Ivanisevic J., Schneider B.L., Diano S., Cota D. and Schoonjans K.* Central anorexigenic actions of bile acids are mediated by TGR5. Nature Metabolism 2021, 3, 595–603.  [DOI]

Carrard J., Gallart-Ayala H., Infanger D., Teav T., Wagner J., Knaier R., Colledge F., Streese L., Königstein K., Hinrichs T., Hanssen H., Ivanisevic J.* and Schmidt-Trucksäss A.* Metabolic View on Healthspan: Lipidome-wide Association Study. 2021, Metabolites 11:5, 287. [DOI]

van der Velpen V., Rosenberg N., Maillard V., Teav T., Chatton J-Y., Gallart-Ayala H.* and Ivanisevic J.* Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC-MS. 2021, Journal of Neurochemistry 00:1-11. [DOI]

Bararpour N., Gilardi F., Carmeli C., Sidibe J., Ivanisevic J., Caputo T., Augsburger M., Grabherr S., Desvergne B., Guex N., Bochud M. and Thomas A.* DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies. 2021, Scientific reports, 11 (1) p. 5657. [DOI]

Carrard J., Guerini C., Appenzeller-Herzog C., Infanger D., Königstein K., Streese L., Hinrichs T., Hanssen H., Gallart-Ayala H., Ivanisevic J. and Schmidt-Trucksäss A.The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis. 2021, BMJ open sport & exercise medicine, 7 (1) pp. e001008. [DOI]

Gallart-Ayala H., Teav T. and Ivanisevic J.* Hydrophilic Interaction Chromatography - Mass Spectrometry (HILIC-MS) Approaches for Probing the Polar Metabolome. Chapter in the Book Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome. Edited by Rawi Ramautar, The Royal Society of Chemistry 2021


Medina J., van der Velpen V., Teav T., Guitton Y., Gallart-Ayala H.* and Ivanisevic J.* Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome. 2020, Metabolites 10:12, 495. [DOI]

Gallart-Ayala H., Teav T., Ivanisevic J.*, Metabolomics meets Lipidomics: Assessing the Small Molecule Component of Metabolism. 2020, BioEssays 42:12. [DOI]

Chevalier C., Kieser S., Çolako─člu M., Hadadi N., Brun J., Rigo D., Suárez-Zamorano N., Spiljar M., Fabbiano S., Busse B., Ivanisevic J., Macpherson A., Bonnet N., Trajkovski M.*, Warmth Prevents Bone Loss through the Gut Microbiota. 2020, Cell Metabolism 32:4, 575-590. [DOI]

Hadadi N., Pandey V., Chiappino Pepe A., Morales M., Gallart-Ayala H., Mehl F., Ivanisevic J., Sentchilo V. and van der Meer J.* Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models. 2020, Systems Biology and Applications 6, 1. [DOI]


Ivanisevic J.* and Want E.* From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data, Metabolites 2019, 9, 12. [DOI]


van der Velpen, V.; Teav, T.; Gallart-Ayala, H.; Mehl, F.; Konz, I.; Clark, C.; Oikonomidi, A.; Peyratout, G.; Henry, H.; Delorenzi, M., Ivanisevic J.* and Popp J.* Systemic and central nervous system metabolic alterations in Alzheimer’s disease. Alzheimer's Research & Therapy 2019, 11, 93. [DOI]


Teav, T., Gallart-Ayala, H., van der Velpen, V., Mehl, F., Henry, H.* and Ivanisevic, J.* Merged Targeted Quantification and Untargeted Profiling for Comprehensive Assessment of Acylcarnitine and Amino Acid Metabolism. Analytical Chemistry 2019, 91, 11757-11769. [DOI]


Cianciaruso, C., Beltraminelli, T., Duval, F., Nassiri, S., Hamelin, R., Mozes, A., Gallart-Ayala, H., Ceada Torres, G., Torchia, B., Ries, C.H., Ivanisevic J. and de Palma M.* Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Reports 2019, 27, 3062-3080.e3011. [DOI]

Rinschen M., Ivanisevic J., Giera M.* and Siuzdak G.* Identification of bioactive metabolites using activity metabolomics. Nature Reviews Molecular Cell Biology 2019, 20:6, 353-367. [DOI]

Cudré-Cung H-P., Remacle N., do Vale-Pereira S., Gonzalez M., Henry H., Ivanisevic J., Schmiesing J., Mühlhausen C., Braissant O., Ballhausen D.* Ammonium accumulation and chemokine decrease in culture media of Gcdh−/− 3D reaggregated brain cell cultures. Molecular Genetics and Metabolism 2019, 126:4, 416-428. [DOI]


Katsyuba, E.,  Mottis, A.,  Zietak, M., De Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O.,  Liscio, P., Giacchè, N., Stokar-Regenscheit, N., Legouis, D., de Seigneux, S., Ivanisevic, J., Raffaelli, N., Schoonjans, K., Pellicciari, R., & Auwerx J.* De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature. 2018; 563, 354-359. [DOI]

Gómez C.*, Gallart-Ayala H.*, Metabolomics: a tool to characterize the effect of phthalates and bisphenol A. Environmental Reviews. 2018; 26 (4) 351-357. [DOI]

Mehl F., Gallart-Ayala H., Konz I., Teav T., Oikonomidi A., Peyratout G., van der Velpen V., Popp J., Ivanisevic J.* LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid. Data in brief. 2018, 1358-1362. [DOI]

Domingo-Almenara X., Montenegro-Burkea J.R., Ivanisevic J., Thomas A., Sidibé J., Teav T., Guijas C., Aisporna A.E., Rinehart D., Hoang L., Nordström A., Góomez-Romero M., Whiley L., Lewis M.R., Nicholson J.K., Benton H.P.* and Siuzdak G.* METLIN-MRM and XCMS-MRM: a cloud library and public resource for targeted analysis of small molecules. Nature Methods 2018, 15, 681–684. [DOI]

Remacle N., Forny P., Cudré-Cung H.P., Gonzalez-Melo M., Vale-Pereira S., Henry H., Teav T., Gallart-Ayala H., Braissant O., Baumgartner M. and Ballhausen D.* New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria. Molecular Genetics and Metabolism 2018, 124, 266-277. [DOI]

Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B. and Siuzdak G.* Autonomous Multi-Modal Metabolomics Data Integration for Comprehensive Pathway Analysis. Analytical Chemistry. 2018; 90, 14, 8396-8403. [DOI]

Gallart-Ayala H., Konz I., Mehl F., Teav T., Oikonomidi A., Peyratout G., van der Velpen V, Popp J. and Ivanisevic J.* A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects. Analytica Chimica Acta. 2018, 1037, 327-337. [DOI]

Ivanisevic J.* and Thomas A.* Metabolomics as a Tool to Understand Pathophysiological Processes. Clinical Metabolomics. Methods Molecular Biology. 2018;1730:3-28. [DOI][Pubmed]


Liu P-S, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng W-C, Chou C-H, Vavakova M, Muret C, Debackere K, Mazzone M, Huang H-D, Fendt S-M, Ivanisevic J and Ho P-C.* α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nature Immunology 2017,18:985. [DOI][Pubmed]

Huan T., Forsberg E.M., Rinehart D., Johnson C. H. , Ivanisevic J., Benton H.P., Fang M., Aisporna A., Hilmers B., Poole F.L., Thorgersen M.P., Adams M.W.W., Krantz G., Fields M.W., Robbins P.D., Niedernhofer L.J., Ideker T., Majumder E.L., Wall J.D., Rattray N.J.W., Goodacre R., Lairson L.L. and Siuzdak G.* Systems biology guided by XCMS Online metabolomics. Nature Methods 2017, 14, 461–462. [DOI] [Pubmed]

Montenegro-Burke J.R., Aisporna A.E., Benton H.P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B.T., Ivanisevic J., Wolan D.W., Teyton L., Lairson L. and Siuzdak G.* Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes. Analytical chemistry 2017, 89 (2) pp. 1254-1259. [DOI] [Pubmed]


Cudré-Cung H.P., Zavadakova P., do Vale-Pereira S., Remacle N., Henry H., Ivanisevic J., Tavel D., Braissant O., Ballhausen D.* Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. Molecular Genetics and Metabolism 2016, 119:1-2, 57-67. [DOI] [Pubmed]

Ivanisevic J.*, Stauch K.L. , Petrascheck M. , Benton H.P. , Epstein A.A. , Fang M. , Gorantla S. , Tran M. , Hoang L. , Kurczy M.E., Boska M.D., Gendelman H.E., Fox, H.S.* and Siuzdak G.* Metabolic drift in the aging brain. Aging 2016, 8:5, 1000-1020. [DOI][Pubmed]

Johnson C.H., Ivanisevic J., Siuzdak G.* Metabolomics: beyond biomarkers and towards mechanisms. Nature Reviews Molecular Cell Biology 2016, 17:7, 451-459. [DOI][Pubmed]

Kurczy M.E. , Forsberg E.M. , Thorgersen M.P. , Poole F.L. , Benton H.P. , Ivanisevic J. , Tran M.L. , Wall J.D. , Elias D.A. , Adams M.W. and Siuzdak G.* Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation. Acs Chemical Biology 2016, 11:6, 1677-85. [DOI][Pubmed]

Fang M. , Ivanisevic J. , Benton H.P. , Johnson C.H. , Patti G.J. , Hoang L.T. , Uritboonthai W. , Kurczy M.E. , Siuzdak G.* Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. Analytical Chemistry 2016, 87:21, 10935-41. [DOI][Pubmed]


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