RECENT PUBLICATIONS (since Platform creation in 2016 onwards)


Hadadi N., Pandey V., Chiappino Pepe A., Morales M., Gallart-Ayala H., Mehl F., Ivanisevic J., Sentchilo V. and van der Meer J.* Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models. Systems Biology and Applications 2019, 6, 1. [DOI]


Ivanisevic J.* and Want E.* From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data, Metabolites 2019, 9, 12. [DOI]


van der Velpen, V.; Teav, T.; Gallart-Ayala, H.; Mehl, F.; Konz, I.; Clark, C.; Oikonomidi, A.; Peyratout, G.; Henry, H.; Delorenzi, M., Ivanisevic J.* and Popp J.* Systemic and central nervous system metabolic alterations in Alzheimer’s disease. Alzheimer's Research & Therapy 2019, 11, 93. [DOI]


Teav, T., Gallart-Ayala, H., van der Velpen, V., Mehl, F., Henry, H.* and Ivanisevic, J.* Merged Targeted Quantification and Untargeted Profiling for Comprehensive Assessment of Acylcarnitine and Amino Acid Metabolism. Analytical Chemistry 2019, 91, 11757-11769. [DOI]


Cianciaruso, C., Beltraminelli, T., Duval, F., Nassiri, S., Hamelin, R., Mozes, A., Gallart-Ayala, H., Ceada Torres, G., Torchia, B., Ries, C.H., Ivanisevic J. and de Palma M.* Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Reports 2019, 27, 3062-3080.e3011. [DOI]

Rinschen M., Ivanisevic J., Giera M.* and Siuzdak G.* Identification of bioactive metabolites using activity metabolomics. Nature Reviews Molecular Cell Biology 2019, 20:6, 353-367. [DOI]

Cudré-Cung H-P., Remacle N., do Vale-Pereira S., Gonzalez M., Henry H., Ivanisevic J., Schmiesing J., Mühlhausen C., Braissant O., Ballhausen D.* Ammonium accumulation and chemokine decrease in culture media of Gcdh−/− 3D reaggregated brain cell cultures. Molecular Genetics and Metabolism 2019, 126:4, 416-428. [DOI]


Katsyuba, E.,  Mottis, A.,  Zietak, M., De Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O.,  Liscio, P., Giacchè, N., Stokar-Regenscheit, N., Legouis, D., de Seigneux, S., Ivanisevic, J., Raffaelli, N., Schoonjans, K., Pellicciari, R., & Auwerx J.* De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature. 2018; 563, 354-359. [DOI]

Gómez C.*, Gallart-Ayala H.*, Metabolomics: a tool to characterize the effect of phthalates and bisphenol A. Environmental Reviews. 2018; 26 (4) 351-357. [DOI]

Mehl F., Gallart-Ayala H., Konz I., Teav T., Oikonomidi A., Peyratout G., van der Velpen V., Popp J., Ivanisevic J.* LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid. Data in brief. 2018, 1358-1362. [DOI]

Domingo-Almenara X., Montenegro-Burkea J.R., Ivanisevic J., Thomas A., Sidibé J., Teav T., Guijas C., Aisporna A.E., Rinehart D., Hoang L., Nordström A., Góomez-Romero M., Whiley L., Lewis M.R., Nicholson J.K., Benton H.P.* and Siuzdak G.* METLIN-MRM and XCMS-MRM: a cloud library and public resource for targeted analysis of small molecules. Nature Methods 2018, 15, 681–684. [DOI]

Remacle N., Forny P., Cudré-Cung H.P., Gonzalez-Melo M., Vale-Pereira S., Henry H., Teav T., Gallart-Ayala H., Braissant O., Baumgartner M. and Ballhausen D.* New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria. Molecular Genetics and Metabolism 2018, 124, 266-277. [DOI]

Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B. and Siuzdak G.* Autonomous Multi-Modal Metabolomics Data Integration for Comprehensive Pathway Analysis. Analytical Chemistry. 2018; 90, 14, 8396-8403. [DOI]

Gallart-Ayala H., Konz I., Mehl F., Teav T., Oikonomidi A., Peyratout G., van der Velpen V, Popp J. and Ivanisevic J.* A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects. Analytica Chimica Acta. 2018, 1037, 327-337. [DOI]

Ivanisevic J.* and Thomas A.* Metabolomics as a Tool to Understand Pathophysiological Processes. Clinical Metabolomics. Methods Molecular Biology. 2018;1730:3-28. [DOI][Pubmed]


Liu P-S, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng W-C, Chou C-H, Vavakova M, Muret C, Debackere K, Mazzone M, Huang H-D, Fendt S-M, Ivanisevic J and Ho P-C.* α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nature Immunology 2017,18:985. [DOI][Pubmed]

Huan T., Forsberg E.M., Rinehart D., Johnson C. H. , Ivanisevic J., Benton H.P., Fang M., Aisporna A., Hilmers B., Poole F.L., Thorgersen M.P., Adams M.W.W., Krantz G., Fields M.W., Robbins P.D., Niedernhofer L.J., Ideker T., Majumder E.L., Wall J.D., Rattray N.J.W., Goodacre R., Lairson L.L. and Siuzdak G.* Systems biology guided by XCMS Online metabolomics. Nature Methods 2017, 14, 461–462. [DOI] [Pubmed]

Montenegro-Burke J.R., Aisporna A.E., Benton H.P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B.T., Ivanisevic J., Wolan D.W., Teyton L., Lairson L. and Siuzdak G.* Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes. Analytical chemistry 2017, 89 (2) pp. 1254-1259. [DOI] [Pubmed]


Cudré-Cung H.P., Zavadakova P., do Vale-Pereira S., Remacle N., Henry H., Ivanisevic J., Tavel D., Braissant O., Ballhausen D.* Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. Molecular Genetics and Metabolism 2016, 119:1-2, 57-67. [DOI] [Pubmed]

Ivanisevic J.*, Stauch K.L. , Petrascheck M. , Benton H.P. , Epstein A.A. , Fang M. , Gorantla S. , Tran M. , Hoang L. , Kurczy M.E., Boska M.D., Gendelman H.E., Fox, H.S.* and Siuzdak G.* Metabolic drift in the aging brain. Aging 2016, 8:5, 1000-1020. [DOI][Pubmed]

Johnson C.H., Ivanisevic J., Siuzdak G.* Metabolomics: beyond biomarkers and towards mechanisms. Nature Reviews Molecular Cell Biology 2016, 17:7, 451-459. [DOI][Pubmed]

Kurczy M.E. , Forsberg E.M. , Thorgersen M.P. , Poole F.L. , Benton H.P. , Ivanisevic J. , Tran M.L. , Wall J.D. , Elias D.A. , Adams M.W. and Siuzdak G.* Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation. Acs Chemical Biology 2016, 11:6, 1677-85. [DOI][Pubmed]

Fang M. , Ivanisevic J. , Benton H.P. , Johnson C.H. , Patti G.J. , Hoang L.T. , Uritboonthai W. , Kurczy M.E. , Siuzdak G.* Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. Analytical Chemistry 2016, 87:21, 10935-41. [DOI][Pubmed]


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