RECENT PUBLICATIONS (since Platform creation in 2016 onwards)


Rinschen M., Ivanisevic J., Giera M., Siuzdak G. Identification of bioactive metabolites using activity metabolomics. Nature Reviews Molecular Cell Biology. In press 2019 [DOI]

Cudré-Cung H-P., Remacle N., do Vale-Pereira S., Gonzalez M., Henry H., Ivanisevic J., Schmiesing J., Mühlhausen C., Braissant O., Ballhausen D. Ammonium accumulation and chemokine decrease in culture media of Gcdh−/− 3D reaggregated brain cell cultures. Molecular Genetics and Metabolism. In press 2019 [DOI]


Katsyuba, E.,  Mottis, A.,  Zietak, M., De Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O.,  Liscio, P., Giacchè, N., Stokar-Regenscheit, N., Legouis, D., de Seigneux, S., Ivanisevic, J., Raffaelli, N., Schoonjans, K., Pellicciari, R., & Auwerx J. De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature. 2018; 563, 354-359. [DOI]

Gómez C., Gallart-Ayala H., Metabolomics: a tool to characterize the effect of phthalates and bisphenol A. Environmental Reviews. 2018; 26 (4) 351-357. [DOI]

Mehl F., Gallart-Ayala H., Konz I., Teav T., Oikonomidi A., Peyratout G., van der Velpen V., Popp J., Ivanisevic J., LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid. 2018/12. Data in brief. 2018; 1358-1362. [DOI]


Domingo-Almenara X., Montenegro-Burkea J.R., Ivanisevic J., Thomas A., Sidibé J., Teav T., Guijas C., Aisporna A.E., Rinehart D., Hoang L., Nordström A., Góomez-Romero M., Whiley L., Lewis M.R., Nicholson J.K., Benton H.P. and Siuzdak G. METLIN-MRM and XCMS-MRM: a cloud library and public resource for targeted analysis of small molecules. Nature Methods. 2018; 15, 681–684. [DOI]

Remacle N., Forny P., Cudré-Cung H.P., Gonzalez-Melo M., Vale-Pereira S., Henry H., Teav T., Gallart-Ayala H., Braissant O., Baumgartner M. and Ballhausen D. New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria. Molecular Genetics and Metabolism. 2018; 124, 266-277. [DOI]

Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B. and Siuzdak G. Autonomous Multi-Modal Metabolomics Data Integration for Comprehensive Pathway Analysis. Analytical Chemistry. 2018; 90, 14, 8396-8403. [DOI]

Gallart-Ayala H., Konz I., Mehl F., Teav T., Oikonomidi A., Peyratout G., van der Velpen V, Popp J. and Ivanisevic J. A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects. Analytica Chimica Acta. 2018; 1037, 327-337. [DOI]

Ivanisevic J and Thomas A. Metabolomics as a Tool to Understand Pathophysiological Processes. Clinical Metabolomics. Methods Molecular Biology. 2018;1730:3-28. [DOI][Pubmed]


Liu P-S, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng W-C, Chou C-H, Vavakova M, Muret C, Debackere K, Mazzone M, Huang H-D, Fendt S-M, Ivanisevic J and Ho P-C. α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nature Immunology 2017,18:985. [DOI][Pubmed]

Huan T., Forsberg E.M., Rinehart D., Johnson C. H. , Ivanisevic J., Benton H.P., Fang M., Aisporna A., Hilmers B., Poole F.L., Thorgersen M.P., Adams M.W.W., Krantz G., Fields M.W., Robbins P.D., Niedernhofer L.J., Ideker T., Majumder E.L., Wall J.D., Rattray N.J.W., Goodacre R., Lairson L.L. & Siuzdak G., 2017. Systems biology guided by XCMS Online metabolomics. Nature Methods, 14, 461–462. [DOI] [Pubmed]

Montenegro-Burke J.R., Aisporna A.E., Benton H.P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B.T., Ivanisevic J. et al., 2017. Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes. Analytical chemistry, 89 (2) pp. 1254-1259. Peer-reviewed.
[DOI] [Pubmed]


Cudré-Cung H.P., Zavadakova P., do Vale-Pereira S., Remacle N., Henry H., Ivanisevic J., Tavel D., Braissant O., Ballhausen D., 2016  Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria. Molecular Genetics and Metabolism,  [DOI] [Pubmed]

Ivanisevic J. , Stauch K.L. , Petrascheck M. , Benton H.P. , Epstein A.A. , Fang M. , Gorantla S. , Tran M. , Hoang L. , Kurczy M.E. et al., 2016. Metabolic drift in the aging brain. Aging.

Johnson C.H. , Ivanisevic J. , Siuzdak G., 2016. Metabolomics: beyond biomarkers and towards mechanisms. Nature Reviews. Molecular Cell Biology.

Kurczy M.E. , Forsberg E.M. , Thorgersen M.P. , Poole F.L. , Benton H.P. , Ivanisevic J. , Tran M.L. , Wall J.D. , Elias D.A. , Adams M.W. et al., 2016. Global Isotope Metabolomics Reveals Adaptive Strategies for Nitrogen Assimilation. Acs Chemical Biology. [DOI][Pubmed]

Fang M. , Ivanisevic J. , Benton H.P. , Johnson C.H. , Patti G.J. , Hoang L.T. , Uritboonthai W. , Kurczy M.E. , Siuzdak G., 2015. Thermal Degradation of Small Molecules: A Global Metabolomic Investigation. Analytical Chemistry.




Julijana Ivanisevic                               Tony Teav

Hector Gallart Ayala                            Vera van der Velpen

Florence Mehl

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