Exercise biology

  • Animal models
  • Cellular and molecular mechanisms
  • Genetics and epigenetics
  • Biological pathways and sports metabolism

This theme examines fundamental aspects of physical exercise at the molecular level. Our research uses cellular and animal models to investigate the mechanisms underlying the adaptations produced by training and, conversely, by physical inactivity. We can then transfer our findings from the model to humans (including patients) or vice-versa (translational research).


Researchers working on this theme:

  • Francesca Amati – Associate professor
  • Yoan Arribat – Post-doctoral researcher
  • Sonia Conde Alonso - Doctoral student
  • Bengt Kayser - Full professor
  • Sylviane Lagarrigue - Post-doctoral researcher
  • Jessica Lavier - Doctoral student
  • Lucia Mazzolai – Professor
  • Daria Neyroud - Doctoral student
  • Maxime Pellegrin – Research fellow
  • Nicolas Place - Assistant professor
  • Nadège Zanou - Post-doctoral researcher


Major publications on this research theme:

  • Broskey NT, Boss A, Fares EJ, Greggio C, Gremion G, Schlüter L, Hans D, Kreis R, Boesch C and F.  Amati. Exercise efficiency relates with mitochondrial content and function in older adults. Physiol Rep. 2015 Jun;3(6).
  • Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, Hans D, Gremion G, Kreis R, Boesch C, Canto C, Amati F. Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. J Clin Endocrinol Metab. 2014 May;99(5):1852-61.
  • Broskey NT, Daraspe J, Humbel BH and Amati F. Skeletal muscle mitochondrial and lipid droplet content assessed with standardized grid sizes for stereology. J Appl Physiol, 2013, Sep; 115(5): 765-70.
  • Diserens G, Vermathen M, Precht C, Broskey NT, Boesch C, Amati F, Dufour JF and Vermathen P. Separation of small metabolites and lipids in spectra from biopsies by diffusion-weighted HR-MAS NMR: a feasibility study.  Analyst, 2015 Jan 7;140(1):272-9.
  • Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J, Cantó C and Amati F. Enhanced respiratory chain supercomplexes formation in response to exercise in human skeletal muscle. Cell metabolism. Accepted october 14, 2016.
  • Neyroud D, Cheng AJ, Bourdillon N, Kayser B, Place N, Westerblad H. Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles. Front Physiol. 2016 Jun 28;7:252.
  • Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng AJ, Ochala J, Kamandulis S, Girard S, Volungevičius G, Paužas H, Mekideche A, Kayser B, Martinez-Redondo V, Ruas JL, Bruton J, Truffert A, Lanner JT, Skurvydas A, Westerblad H. Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise. PNAS, 2015 Dec 15;112(50):15492-7.


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