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Thursday June 23, 2022
09:30 Welcome - Jolanda van Leeuwen
Session 1 – Variants
Chair: Jolanda van Leeuwen
09:45-10:30 Lars Steinmetz, EMBL Stanford (USA)
"Novel technologies to functionally catalogue our genome - nucleotide by nucleotide"
10:30-11:15 Hannah Carter, University of California San Diego (USA)
“Common germline immune variants contribute to selective constraint on tumor
genomes”
11:15-12:00 Jing Hou, University of Strasbourg / CNRS (FR)
“Background-dependent gene essentiality and beyond”
12:00-12:10 Presentation of the Prix Henri Guenin - Aleksandar Vjestica
12:10-13:30 Lunch and Poster session
Session 2 – Genes
Chair: Sebastian Soyk
13:30-14:15 Charlie Boone, University of Toronto (CA)
“Large-scale analysis of genetic networks in yeast and human cells”
14:15-15:00 Maitreya Dunham, University of Washington (USA)
“The role of genetic interactions in differences in gene essentiality between yeast
species”
15:00-15:45 Yolanda Schaerli, UNIL, Lausanne (CH)
“Interactions in synthetic pattern-forming gene regulatory networks”
15:45-16:15 Break
Session 3 – Short talks: the future of research on biological interactions
Chair: Aleksandar Vještica
16:15-16:30 (15 min) Talk #1 from selected abstract:
Gwen Swinnen, UNIL, Lausanne (CH)
"Revealing cryptic genetic modifiers that affect flower production in tomato"
16:35-16:50 (15 min) Talk #2 from selected abstract
Georgia Katsioudi, UNIL, Lausanne (CH)
"Nonsense-mediated mRNA decay regulates circadian timekeeping in mammals"
16:55-17:10 (15 min) Talk #3 from selected abstract
Athéna Sklias, UNIL, Lausanne (CH)
"Comprehensive map of ribosomal RNA 2’-O methylation and associated SNORDs
in Drosophila melanogaster"
17:15-17:30 (15 min) Talk #4 from selected abstract
Manuel Kaulich, Goethe University Frankfurt (DE)
"Optimized metrics for combinatorial CRISPR screens identify directional genetic
dependencies"
Friday June 24, 2022
Session 4 – Regulation
Chair: Yolanda Schaerli
09:30-10:15 Judith Zaugg, EMBL Heidelberg (DE)
“Cell-type specific regulatory networks to investigate disease mechanisms”
10:15-11:00 Nadav Ahituv, University of California San Francisco (USA)
“Functional characterization and therapeutic targeting of gene regulatory elements”
11:00-11:45 Bart Deplancke, EPFL, Lausanne (CH)
“Resolving the molecular mechanisms underlying regulatory variation-mediated
phenotypic diversity”
11:45-13:00 Lunch & poster session
Session 4 – Proteins
Chair: Alexandre Reymond
13:00-13:45 Alexandra Bendel (Guillaume Diss' lab), FMI, Basel (CH)
“Deep mutational scanning of entire human protein interaction domain families”
13:45-14:30 Yifat Merbl, Weizmann Institute of Science (IL)
“From epiProteomics to precision oncology”
14:30-15:15 Marc Vidal, Dana-Farber Cancer Institute (USA) - online
“Targeting protein-protein interactions in HDAC complexes”
15:15-15:30 Concluding remarks - Alexandre Reymond
