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Involvement of the natriuretic peptides in vascular and cardiac homeostasis: Role of the C-type Natriuretic Peptide in the development of the vascular phenotype in Marfan disease

Androgen signaling in skin cancer susceptibility

Mitochondria & Energy Metabolism: PhD student position in mitochondrial biology, innate immunity and immunometabolism 

Mechanisms of inflammation: Inflammatory pathways leading to autoinflammation

Investigating the impact of tanycyte Efna5 on hypothalamic neurons regulating food intake in mice

Investigating the role of epigenetic dysregulation as driver of aging and developing anti-aging interventions based on reprogramming

Cell-penetrating peptide and homeoprotein uptake mechanisms

Structure, function and evolution of neural circuits

The role of CDK4 in the metabolism of the brain

Molecular mechanisms underlying light-regulated plant growth and development: In dense vegetation plants compete for access to sunlight. We study the signaling mechanisms triggered by photosensory receptors in the model plant Arabidopsis thaliana. Our main focus is the shade avoidance response and phototropism.

Molecular basis of gene regulation specificity: Regulatory elements that activate or silence gene transcription are promiscuous and can act over long genomic distances in animals. We study how chromosome folding in 3D affects gene regulation specificity in Drosophila.

Translational regulation in circadian timekeeping and disease

Genome structure and expression:  Identification of genetic variants associated with autosomal recessive intellectual disability

Modulation of stem cell control during crop domestication

Systematic analysis of genetic interactions: High-throughput genetic analyses in either yeast or cultured cell lines, depending on the interest of the student. Please have a look at the lab website.

- Organization of transcriptional activity in nuclear space

- Biophysics of transcriptional hotspots

- Characterization of protein networks that activate embryonic transcription

New treatment strategies to cure the creatine transporter (SLC6A8) deficiency

Brain health and plasticity

Technology-assisted personalized cognitive assessment and neurorehabilitation

At the interface between biology and computer science, our laboratory seeks to better understand evolutionary and functional relationships between genes, genomes, and species. We have a number of ongoing projects in the lab—the research project will be discussed depending on the skills and interests of the candidates

Molecular mechanism of neuronal secretion

Ancient DNA and population genetics:  Characterize the peopling of ancient Greece
Characterize Denisovan and Neanderthal admixture in Oceanian populations
Estimate contamination based on mtDNA and whole genome data

The aims of the project is to investigate the comparative genomics of clownfishes and damselfishes by developing new approach to link phenotypic traits with large scale genomic data

Ecology and evolution of myrmecomorphy

Social evolution in ants - Evolutionary genomics/behaviour: Evolution of a supergene controlling social organization in ants
Behavioural and genetic underpinnings of queen number variation in ants

Mining the barn owl genome for traces of selection at different scales

Adaptation to malnutrition; sexual selection and conflict

Genomics of social behaviour Division of labour in social insects

Plant evolution: The evolution of monoecy in flowering plants - models and comparative analyses

Evolutionary bioinformatics: Bioinformatics of animal evo-devo, specific subject to determine with the candidate

Genomics of colour polymorphism and population genomics. 
Navigation ecology in a nocturnal  predator.

Effects of the mycorrhizal symbiosis on plant ecology, soil formation and soil carbon storage

Evolutionary Conservation Biology

Gestational diabetes, lifestyle behavior and metabolic health outcomes: Relationships between eating behavior, brain responses to food viewing, and metabolic health outcomes in women with gestational diabetes 

We have multiple projects on the roles of the Nrf2 antioxidant response in the thyroid gland. As models we use human samples, mice, and conventional and 3D organoid cell cultures.

The goal of this study is to combine fetal medicine and forensic genetics to characterize pregnancy induced DNA microchimerism and to assess DNA-based markers for non-invasive prenatal paternity testing. Analytical approch will include massive parallel sequencing

Microbiome research and animal-microbe symbiosis: Metabolic crosstalk between the gut microbiota and the host; Ecology and evolution of the gut microbiota; Wet laba nd bioinformatics; Multi-omics analyses

Role of Cdc42 GTPase in cell polarization and cell fusion

The evolution of antibiotic resistance within microbial communities

Bacterial Synthetic Biology: Several projects are available including: -synthetic (CRISPR-based) circuits for pattern formation -engineered living materials -using synthetic biology to study molecular evolution

Our work is centered on the role of the microbiota and the gut ecosystem in different forms of malnutrition in order to contribute to the understanding of the syndromes and harness then this knowledge to develop powerful interventions strategies and treatments. We are also more generally interested in the role of the microbiota in  the triad linking gut health, infection and nutrition. To this purpose, we perform clinical/translational projects, especially in low-and middle income countries (LMIC) and analyze the underlying molecular mechanisms using in vitro and in vivo models. Further, we work on developing tools to work with the human microbiota as well as microbiota-targeted interventions. The proposed project aims to contribute to this effort by screening for prebiotic substances that allow boosting the growth of given bacterial strains and communities of interest.

Regulatory mechanisms orchestrating synapse formation, plasticity, and social behaviours

Neuron-astrocyte metabolic interactions in physiological and pathological conditions (Alzheimer's disease and epilepsy): Our lab is investigating the metabolic dialog between neurons and astrocytes in rodent and human brains. We study the signaling that involves metabolites and the mitochondrial function, and develop strategies to alleviate the impact of Alzheimer's disease and epilepsy.

Role of autophagy in oligodendrocytes in perinatal brain injuries

Computational biology for cancer immunology:
- Analysis of single-cell RNA-Seq data - Predictions of neo-antigens
- Analysis of TCR repertoire and TCR specificity

Metabolic guidance on T cell differentiation in anti-viral and anti-tumor responses

Immune-vascular cross talk and tumor microenvironment:
Subject 1: Biomechanical control of (lymph)angiogenesis.
Subject 2: Immune-vascular cross-talk in development and tumorigenesis. 

Molecular virology and pathogenesis of hepatitis C and E: Investigating the host partners of hepatitis E virus (HEV) required for a productive viral life cycle

Role of genital microbiota in fertility and infertility

- Death and dying in medicine (specific topic, already 1 candidate)
- Social and historical studies of medicine

Philosophy and ethics of medicine

Engineering human T cells to target hematologic malignancies

Innate immune training and host defenses against infections towards new biomarkers to improve sepsis management

Decision making processes in the human and the small rodents, thalamocortical interactions, neural networks dynamics

Effect of class of obesity, body weight vs body mass loss and frictional internal mechanical work on the energetics and mechanics of walking in individuals with obesity 

Molecular adaptations to muscle and vascular functions to exercise with localized or sytemic hypoxia

Investigation of the role of candidate factors on HIV replication identified upon differential methylation and gene expression analysis, i.e. upon epitranscriptomic and transcripomtic charaterization of HIV-infected cells

Investigation of cell division in Acinetobacter species

- "Novel radiopharmaceuticals targeting M2 macrophages in the TME"

- "Development of radiolabeled chemokine antagonists for prognostic imaging and patient selection in the context of immunotherapy"

Multidisciplinary research in occupational hygiene, ergonomy and epidemiology applied to the public transport  activity branch. 
Stratégie energétique et santé (SEnS): impact of technological innovation in public transport on mental and physical health

Multisensory-motor intergration:  Interaction between brain regions in the human brain

Aging and muscle metabolism from the whole organism to organelle contact sites

Psychiatric epidemiology and genetic epidemiology: Comprehensive prediction model of Suicide Attempts derived from a large community sample followed up over 10 years.

Diverse thesis subjects possible. To be discussed with the interested candidate

The regulation of adult hippocampal neurogenesis by astrocytes 

Machine learning for medical image analysis

Sensory and multisensory processes across the human lifespan

Development and optimization of magnetic resonance guided vascular interventions

Translational Magnetic Resonance Imaging Technology Development

Role of T- and B-cell subsets in rejection and tolerance after solid organ transplantation

Implementation of procalcitonin point-of-care test to reduce antibiotic prescription in family medicine

Therapeutic potential of sodium thiosulfate in the treatment of abdominal aortic aneurysm