Assoc. Professor Patrik Michel
Head of Unit
Head of the Laboratory of Clinical Stroke Research Unit
Laboratoire de l’unité de recherche cérébrovasculaire clinique
Service of neurology (NLG)
The Clinical Stroke Research team maintains since 2003 the ASTRAL registry (Acute STroke Registry and Analysis of Lausanne). It contains >5’000 acute stroke patients, each with >300 variables including demographic, clinical,
comorbidity, multimodal imaging, etiological, metabolic and outcome data. CT and more recently MRI-based angiographic and perfusion data are collected and analysed in a detailed manner. We also study the influence of acute revascularization treatments in different situations, frequent and rare stroke mechanisms, and prognostic markers of long-term outcome. The team participates in multiple national and international randomized trials for acute stroke treatment and secondary prevention.
Patrik Michel’s research interests concern clinical stroke syndromes, acute stroke management, acute stroke perfusion and arterial imaging, and stroke prognosis. He and his collaborators have derived the ASTRAL-prognostic, the ASTRAL-occlusion, the ASTRAL-recanalisation and the ASTRAL recurrence scores. Publications on stroke syndromes concern rare stroke causes (air embolism, Doppler-related stroke, hair-dresser strokes, NIHSS zero strokes, amnesic strokes), stroke mimics and chameleons, stroke severity, and early worsening. Regarding prognosis, he has investigated the influence of specific patient features (cardiac failure, haematological values, PFO, insurance type), acute metabolic values (early blood pressure dynamics, hyperglycemia), and of early neuroimaging. In the area of acute stroke treatment, research is performed on the response to thrombolysis and thrombectomy in different populations (stroke severity, renal failure, body weight, arterial occlusion status). Further research interest include acute arterial occlusion patterns, predictors of recanalisation with and without treatment, impact of collaterals and of brain perfusion imaging. He collaborates with several international teams on the methods and clinical value acute perfusion-CT imaging, thrombolysis, thrombectomy, PFO-related stroke and basilar artery occlusion.
Keywords: Stroke, Thrombolysis, Thrombectomy, CT angiography, CT perfusion