portrait-DuPasquier.jpg                            Pot-Kreis.jpg (POT CAROLINE DNC)

Renaud Du Pasquier                            Caroline Pot

Professor                                                Assist. Professor
Head of the Neurology Service              Head of the LNIE laboratory
Head of the LNIS Laboratory            

Laboratory activity

Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system, where all components of the immune system, innate and adaptive, are involved. In addition to genetic factors, environmental ones play a crucial role in triggering this complex disease. In the Laboratories of neuroimmunology, we examine how environmental factors, among which Epstein-Barr virus, gut microbiome or cholesterol metabolites support autoreactivity of B and T cells. To tackle our hypothesis, we use different approaches, including animal models, namely the experimental autoimmune encephalomyelitis, human samples analysis (blood, cerebrospinal fluid, urine, soon stools) of MS patients and a human in vitro model of MS brain, using induced pluripotent stem cells (iPCS).

Bâtiment Champ de l'Air - Rue du Bugnon 21 - CH-1011 Lausanne
Tel. +41 21 314 96 57
Centre Hospitalier Universitaire Vaudois (CHUV)