Renaud Du Pasquier Caroline Pot
Professor Assist. Professor
Head of the Neurology Service Head of the LNIE laboratory
Head of the LNIS Laboratory
Laboratory activity
Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system, where all components of the immune system, innate and adaptive, are involved. In addition to genetic factors, environmental ones play a crucial role in triggering this complex disease. In the Laboratories of neuroimmunology, we examine how environmental factors, among which Epstein-Barr virus, gut microbiome or cholesterol metabolites support autoreactivity of B and T cells. To tackle our hypothesis, we use different approaches, including animal models, namely the experimental autoimmune encephalomyelitis, human samples analysis (blood, cerebrospinal fluid, urine, soon stools) of MS patients and a human in vitro model of MS brain, using induced pluripotent stem cells (iPCS).
