Professor Renaud Du Pasquier
Head of the Neurology Service
Head of the Laboratory of Neuroimmunology/Multiple Sclerosis - LNIS
Laboratoire de Neuroimmunologie/Sclérose en plaques
Service of neurology (NLG)
Service of immunology and allergy (LIA)
Primarily devoted to research in Multiple Sclerosis (MS), our Laboratory studies the interaction between the immune response - with a focus on CD8+ T cells - and environmental factors. Recently, we have established a program of induced pluripotent stem cells (iPSC). Thanks to this tool, several new opportunities open to us, as we are now able to observe central nervous system (CNS) cells of MS patients, which so far were out of reach. We have now the possibility to put auto-reactive peripheral immune cells in contact with autologous CNS cells and be in a position to determine if, indeed, there is recognition of autoantigens in the brain.
The Lab team is also actively involved in the monitoring of the long-term effects of DMTs used in MS on immune responses. Especially, we are trying to understand the interaction between these treatments and the biology of JC virus, the agent of progressive multifocal leukoencephalopathy (PML) to better handle the risk of developing PML. Finally, together with clinicians, the Laboratory holds a research program dealing with the neurocognitive disorders in HIV+ patients.
The research of Prof. Renaud Du Pasquier is driven by the willingness to better understand the pathogenesis of inflammation in the brain, in particular in the field of multiple sclerosis. Only such an understanding will lead to breakthrough treatments.
Keywords: Neuroimmunology, Multiple sclerosis, CD8+ T cells, Induced pluripotent stem cells (iPSC), Epstein-Barr virus, HIV
Unisciences ORCID: 0000-0002-2786-3434