Protein and cell engineering

Patrick BARTH
Ludwig adjunct scientist
Ludwig Institute for Cancer Research Lausanne

Associate Professor

Interfaculty Institute of Bioengegineering (IBI)

EPFL

Phone +41 21 693 9686
Email patrick.barth@epfl.ch

Ludwig.jpg (Print)

 

Research interest

Our lab seeks a predictive understanding at the molecular level of how receptor proteins sense and transduce signals across membranes. We develop and apply new integrated computational-experimental approaches to model and design receptor proteins with novel functions for cell engineering and biotechnological applications.

Selected publications

  • Wang, Y., Barth, P. Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy. Nature Communications. 2015 May 21;6:7196.
  • Feng, X., Barth, P. A topological and conformational stability alphabet for multi-pass membrane proteins. Nature Chemical Biology, 2016 March 12(3):167-73.
  • Barth, P.*, Senes, A.* Toward high-resolution computational design of the structure and function of helical membrane proteins. Nature Structural & Molecular Biology, 2016, June 7 ;23(6):475-80.
  • Feng, X., Ambia, J., Chen, K.Y., Young, M. Barth, P. Computational design of ligand binding membrane receptors with high selectivity (2017) Nature Chemical Biology, 13(7):715-723.
  • Chen K.Y., Zhou F., Fryszczyn B.G., Barth P. Naturally evolved G protein-coupled receptors adopt metastable conformations. (2012) Proc Natl Acad Sci U S A 109(33), 13284-9.

Funding

  • NIH NIGMS
  • Eli Lilly
  • EPFL

Group members

Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
ludwig_cancer_research-logo.svg universite_de_lausanne-logo.svg chuv-logo.svg