Hi-TIDe : Immunopeptidomics

Bassani-Sternberg Lab

Our focus

Our main goal is to identify clinically relevant cancer specific Human Leukocyte Antigen (HLA) ligands that will guide the development of personalized cancer immunotherapy using state of the art proteogenomics and mass-spectrometry (MS) approaches.

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Our projects

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  • We develop proteogenomics and MS-based immunopeptidomics analytical and computational approaches to identify HLA ligands derived from tumor-associated proteins, mutated neoantigens, non-canonical ORFs and post translationally modified peptides.
  • We have initiated fundamental discovery work to elucidate how tumor cells present antigens and what are the bases of tumor immunogenicity in mouse and human.
  • We are investigating the differences between T cell inflamed and non-inflamed tumors in terms of antigen presentation and the antigenic landscape and how drugs modulate the immunopeptidome.
  • We have established a continuous bioinformatics pipeline called NeoDisc enabling direct and personalized identification and prediction of neoantigens by combining genomic information derived from exome-seq analysis and transcriptomics data with measured immunopeptidomics data.
  • We apply our discovery pipeline in the context of phase I clinical vaccine and adoptive T cell therapy trials at the CHUV to identify personalized neoantigens from patient tumor samples.

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News @ Bassani-Sternberg Lab

Academic appointment (2021)

Academic appointment (2021)

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CONTACT

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Michal BASSANI-STERNBERG
Tenure Track Assistant Professor
Group leader
Human integrated tumor immunology discovery engine (Hi-TIDe)

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

Head of clinical mass spectrometry unit, Center of experimental therapeutics, Lausanne University Hospital (CHUV)

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Phone +41 79 900 55 30
E-mail

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CONNECT WITH ME

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Featured Publication ------

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Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Mar-2020 | Chloe Chong, Markus Muller... Michal Bassani-Sternberg

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)