Hi-TIDe : Systems tumor microenvironment & biomarker discovery

Dangaj Lab

Our focus

Our main research interest is to gain a deep understanding of the tumor-intrinsic and extrinsic mechanisms that promote or dampen anti-tumor T cell immunity.

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Our projects

  • Gain deep understanding of the molecular states of human TILs (tumor infiltrating lymphocytes) and the tumor microenvironment at stages of tumor escape or tumor rejection using systems approaches. We study tumors at the steady state but also following T cell therapy and other immunotherapies.
  • Unveil fundamental molecular mechanisms driving T cell dysfunction in tumors at the steady state
  • Characterize tumor and stroma-driven exclusion mechanisms of TILs 
  • Define how genomic alterations (ie homologous recombination repair deficiency, HRD) and tumor heterogeneity regulate TIL inflammation status of tumors

The lab employs orthogonal approaches to discovery, including single cell proteomic, transcriptional and epigenetic interrogation, advanced high dimensional microscopy, topologically referenced transcriptional profiling, 3D tumor organoids and histocultures, mouse models and computational tools  

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KEY PUBLICATIONS

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News @ Dangaj Lab

The dual role of the STING protein in promoting tumor-intrinsic mechanisms

The dual role of the STING protein in promoting tumor-intrinsic mechanisms

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CONTACT

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Denarda DANGAJ
Group leader 
Human integrated tumor immunology discovery engine (Hi-TIDe)

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

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Phone +41 21 314 91 06
E-mail

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CONNECT WITH ME

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)