HERRERA Lab
Our focus
Our group is particularly interested in elucidating the molecular mechanisms by which ionizing radiation modulates tumor immunogenicity, as well as harnessing this attribute of radiation to induce therapeutic synergy with immunotherapy in pre-clinical tumor models and cancer patients. In human and mouse models, we orthogonally investigate the tumor microenvironment before and after radiation therapy and immunotherapy to capture tumor-immune cell interactions and comprehensively examine them in order to discover new pathways associated with successful immunological attack or immune failure. We are also conducting pre-clinical and clinical research on FLASH radiation therapy. We're looking at new ways to boost the therapeutic ratio of FLASH irradiation while also investigating its tissue-protective effects.
KEY PUBLICATIONS
- Herrera, F. G., Ronet, C., Ochoa de Olza, M., Barras, D., Crespo, I., Andreatta, M., Corria-Osorio, J., Spill, A., Benedetti, F., Genolet, R., Orcurto, A., Imbimbo, M., Ghisoni, E., Navarro Rodrigo, B., Berthold, D. R., Sarivalasis, A., Zaman, K., Duran, R., Dromain, C., Prior, J., … Coukos, G. Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy. Cancer discovery (2022)
- Chalabi, M., Cardona, A., Nagarkar, D. R., Dhawahir Scala, A., Gandara, D. R., Rittmeyer, A., Albert, M. L., Powles, T., Kok, M., Herrera, F. G., & imCORE working group of early career investigators. Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials. Annals of oncology : official journal of the European Society for Medical Oncology (2020)
- Herrera, F. G., Bourhis, J., & Coukos, G. Radiotherapy combination opportunities leveraging immunity for the next oncology practice. CA: a cancer journal for clinicians (2017)
- Herrera, F. G., Valerio, M., Berthold, D., Tawadros, T., Meuwly, J. Y., Vallet, V., Baumgartner, P., Thierry, A. C., De Bari, B., Jichlinski, P., Kandalaft, L., Coukos, G., Harari, A., & Bourhis, J. 50-Gy Stereotactic Body Radiation Therapy to the Dominant Intraprostatic Nodule: Results From a Phase 1a/b Trial. International journal of radiation oncology, biology, physics (2019)
- Gaide, O., Herrera, F., Jeanneret Sozzi, W., Gonçalves Jorge, P., Kinj, R., Bailat, C., Duclos, F., Bochud, F., Germond, J. F., Gondré, M., Boelhen, T., Schiappacasse, L., Ozsahin, M., Moeckli, R., & Bourhis, J. Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2022)
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Publications
| Funding |
2023 – 2025 Fondazione San Salvatore “Loss of cell-cycle checkpoints in order to maximize low-dose radiation-induced inflammatory responses and sensitize ovarian cancer to immune checkpoint blockade therapy”. 2023 EORTC spring meeting Lausanne 2022 – 2023 Nanobiotix nanoparticles in combination with FLASH irradiation in mouse models of peritoneal carcinomatosis. 2021 – 2022 BioProtect Israel for the study of the benefits of a rectal balloon spacer in the treatment of prostate cancer patients with stereotactic radiotherapy. 2019 – 2021 Prostate Cancer Foundation Challenge Award (18CHAL08) to study tumor biopsies in the RACIN clinical trial. 2019 – 2022 Bristol Myers Squibb grant. Clinical research grant obtained to carry on the clinical trial RACIN |
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