Rufer Lab members

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Bastien DOIX

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Postdoctoral researcher
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Reserach interest 

My research project is focused at deciphering the impact of TCR-ligand affinity on the functionality of tumor-specific cytotoxic T cells and its optimization to improve immune responses against cancer.

Background

My PhD project was conducted in the lab of Pr Feron at the Université Catholique Louvain, Belgium.

Minh Ngoc DUONG
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Research associate
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Research interest 

I am interested in understanding the T-cell based immune responses against cancer cells or following immunotherapies, using different approaches including single cell sequencing, T cell engineering, affinity measurement and multi-functionality.

Background

Before joining the laboratory of Dr Nathalie Rufer, I obtained my PhD in 2014 from the University Lyon 1, France working on the impact of the adipose micro-environment on the resistance of cancer cells to therapeutic antibodies.

Michael HEBEISEN
Rufer Lab Hebeisen Michael-crop771x731.jpg Research associate
CONTACT ME

Research interest

Our work focuses on understanding the impact of TCR affinity on T cell responsiveness through molecular and structural dissection of TCR-pMHC interactions. We aim at maximizing the function of effector CD8+ T cells by redirecting them with highly potent, tumor-specific TCRs selected and engineered for high reactivity, but low self-reactivity. Careful analysis and selection of those therapeutic TCRs is crucial and will help improve the efficacy of adoptive cell transfer immunotherapy.

Background

I am a passionate researcher and experienced mentor, specialized in T cell-based cancer immunotherapy. I studied biology at the University of Fribourg, Switzerland, where I obtained a Master’s in Developmental Biology (control of Hox genes) in 2001. In 2008, I obtained a PhD in Genetics at McGill University, working on the developmental control of the cell cycle in C. elegans. In 2009, I joined the laboratory of Dr Nathalie Rufer as a postdoctoral fellow, then becoming research associate. Since 2018, I am also a qualified part-time teacher working to spark genuine interest in the next generation of biology students and researchers.

Delphine TARDIVON
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BNF intern
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Research interest

Immunotherapies can induce long-term persisting responses in a fraction of cancer patients. I am particularly interested in deepening our understanding in how cancer cells interact with and reshape immune cells to further improve these therapies.

Background

After a Master’s in Molecular Chemistry at l’Ecole Nationale Supérieure de Chimie de Lille, France and a master’s in life sciences at EPFL, the Swiss Federal Institute of Technology in Lausanne  I undertook a PhD in the laboratory of Pr Radtke at EPFL. During my thesis, I studied the role of Notch1 in the initiation and development of chronic lymphocytic leukemia using a mouse model.

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CONTACT

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Nathalie RUFER
Associate professor
Ludwig adjunct scientist

Laboratory N. Rufer

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

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UNIL +41 21 692 59 77
CHUV +41 79 556 95 45
Email

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The Rufer Lab is based at:

Biopôle
Ch. des Boveresses 155
CH-1066 Epalinges
Switzerland

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)