Cancer vaccine development

KANDALAFT Lab

Our focus

We work on the clinical development of personalized cancer vaccines. The aim is to improve whole tumor lysate vaccination approaches and other personalized cancer vaccine approaches by improving the dendritic cell platform and by choosing the most immunogenic antigen with the most practical preparation to be translated rapidly to the clinic.

The other focus of our lab is to find the best setting to integrate vaccines in the standard of care treatment plan for ovarian cancer patients and to understand the immune fitness of cancer patients and correlate it with vaccination.

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Our projects

  • Improving whole tumor lysate vaccination approaches by enhancing the functionality of DC vaccines through genetic engineering and through comparing the different cross presentation capacity of different types of DCs.
  • Identifying the most effective and feasible personalized antigen for vaccination by understanding the immunogenic effect of oxidation through proteomics and immunopeptidomics in collaboration with Dr. Michal Bassani. Previous work showed that HOCl treatment of tumor cells (prior to lysis) greatly increases their immunogenicity. This work aims to identify what are the molecular and signaling mechanisms driving this improved immunogenicity.

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  • Polymer nanomaterials for antitumor immunotherapy in collaboration with Prof. Harm-Anton Klok (EPFL). This study focuses on the development of nanoparticles for the delivery of autologous oxidized tumor lysate to mount a cancer-specific immune response.

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  • Improving vaccination strategies by integrating vaccines with the standard of care therapy in an ovarian cancer mouse model. 

  • Understanding immune fitness of cancer patients and correlating it with vaccination.

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KEY PUBLICATIONS

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News @ Kandalaft Lab

Academic appointment within the Faculty of Biology and Medicine (2021)

Academic appointment within the Faculty of Biology and Medicine (2021)

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CONTACT

Oncology Lausanne Kandalaft Lab

Lana KANDALAFT
Associate Professor
Ludwig adjunct scientist

Laboratory L. Kandalaft

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

Director of Center of experimental therapeutics, Lausanne University Hospital (CHUV)

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Phone +41 21 314 78 23
Fax +41 21 314 10 33
Email

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CONNECT WITH ME

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)