Joyce Lab members

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Ángel ÁLVAREZ-PRADO

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Postdoctoral researcher
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Research interest 

My current research interests revolve around cancer biology, immunology and genomics, with a particular focus on understanding the immune microenvironment of primary and metastatic brain cancers to envision new therapies against these fatal diseases.

Background

I hold a BSc in Biotechnology from the Universidad de Salamanca, Spain, and a MSc in Molecular Biosciences, from the Universidad Autónoma de Madrid, Spain. In 2018, I received my PhD with Honors at the Universidad Autónoma de Madrid, working on B cell somatic hypermutation and lymphomagenesis under the supervision of Dr Almudena R Ramiro at CNIC, Madrid.

Leire BEJARANO
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Postdoctoral researcher
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Research interest

My main research interest is to identify novel therapies for brain metastasis by targeting the tumor microenvironment. In particular, my project focuses on exploring how to modulate the tumor vasculature to boost immune cell infiltration. 

Background

I performed a BSc degree in Biotechnology at the University of Salamanca, Spain, followed by a MSc degree in Molecular Biomedicine in the Pompeu Fabra University, Barcelona, Spain. I obtained my PhD in the CNIO, Madrid, Spain under the supervision of Prof. Maria Blasco studying telomeres in glioblastoma. In 2019, I joined the Joyce Lab as a postdoctoral researcher.

Marta Joana COSTA JORDAO
Joyce Lab Marta Joana Costa Jordao.jpg Postdoctoral researcher
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Research interest

I am currently exploring the involvement of the CNS lymphatic system in brain tumors.

Background 

I did my PhD research in Neuroimmunology in the lab of Prof. Marco Prinz, University Medical Center of Freiburg, Germany and became very interested in understanding the complexity of immune cells in the central nervous system (CNS) and how they can be modulated to treat brain pathologies, which naturally led me to the Joyce Lab for my postdoc.

Davide CROCI
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PhD student
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Research interest 

I work on cutting-edge imaging technologies to observe the brain tumor microenvironment non-invasively and in real time while assessing the translational potential for the clinical implementation of these techniques.

Background

I studied Biology at ETH in Zürich, Switzerland, for my MSc degree, and worked as intern at Novartis in Basel, Switzerland, before joining the Joyce Lab for my PhD.

Stéphanie DEBAYLE
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Executive secretary
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Benoît DUC
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PhD student
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Research interest 

Modeling and interrogating the tumor microenvironment of non-small cell lung cancer brain metastasis.

Background 

  • Graduate of the University of Lausanne Medical School (2014-2020)
  • Master's thesis on pediatric sarcomas in Pr Nicolò Riggi’s group at the Lausanne University Hospital (2019)
  • Research internship on pediatric sarcomas in Pr Mario Suvà’s group at the Massachusetts General Hospital and Broad Institute of MIT (2020)
Johanna LILJA
Joyce Lab Johanna Lilja-crop1969x2100.jpg Postdoctoral researcher
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Research interest 

I am a postdoctoral researcher in the Joyce Lab since May 2021, investigating the role of vascular-immune crosstalk in cancer progression.

Background

For my PhD, undertaken in Pr Johanna Ivaska’s lab at the University of Turku, Finland, I worked on the role of integrin inactivators in cancer cell motility and the tumour microenvironment, and studied the lethal vulnerabilities in KRAS-mutant cancers.

Roeltje MAAS
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PhD student
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Research interest 

I am a PhD student in the Joyce Lab, and am exploring the tumor immune microenvironmental landscape in human brain malignancies, encompassing low- and high-grade gliomas as well as brain metastatic disease. The approaches I am taking include immunofluorescence staining, for spatial characterization of the immune landscape, as well as RNA sequencing analysis and functional ex vivo assays of the different immune populations.

Background

I obtained my Medical Degree, after completing my Bachelor’s and Master’s Degree in Medicine at the Radboud University, Nijmegen, Netherlands

Matteo MASSARA
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Postdoctoral researcher
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Research interest

I am currently exploring the targeting of different communication mechanisms between brain metastasis and the tumor microenvironment. 

Background 

I received my PhD in "Experimental Medicine and Medical Biotechnologies" at the University of Milan and Humanitas Research Hospital, Italy, investigating chemokine receptors involved in the anti-metastatic activity exerted by neutrophils.

Klara SOUKUP
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Research associate
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Research interest

My research interests center around the role of immune cells in tumor development. In the Joyce Lab, I am currently studying how neutrophils regulate the formation of metastases in the brain. 

Background 

I undertook my PhD research at the St Anna Children’s Cancer Research Institute in Vienna, Austria, and obtained my degree from the University of Natural Resources and Life Sciences (BOKU), Vienna.

Spencer WATSON
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Postdoctoral researcher
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Research interest

My research in the Joyce Lab centers on how the wound healing processes of the brain respond to multiple anti-glioblastoma treatments, and how these reactions can ultimately modulate cancer recurrence. My work focuses on the interactions between many of the cell types within the complex tumor microenvironment. To address this complexity, I developed novel methods of high-dimensional imaging that profile how the spatial organization of tumors change in response to treatment.

Background

I am originally from the UK and US, and studied biology and genetics at the University of Oregon, USA. I received a PhD in Cancer Biology from Oregon Health & Science University with a focus on systems biology and bioengineering.

Vladimir WISCHNEWSKI
Joyce Lab Vladimir Wischnewski-crop941x1020.jpg PhD student
CONTACT ME

Research interest

My PhD research in the Joyce Lab focuses on understanding the role that T-lymphocytes play in brain tumors with the ultimate goal of therapeutically improving their anti-tumor function.

Background

I studied Molecular Medicine at the University of Freiburg, Germany, with an emphasis in oncology. My master’s thesis focused on the effects of irradiation on the efficacy of immunotherapy.

Anoek ZOMER
Joyce Lab Anoek Zomer-crop3464x3294.jpg Postdoctoral researcher
CONTACT ME

Research interest 

In the Joyce Lab, I have been using the expertise I gained through my PhD to set up a multimodal in vivo imaging approach combining MRI and 2-photon intravital imaging through cranial imaging windows. Together with other methodologies including single cell sequencing, extensive flow cytometry analyses and proteomics, I am currently investigating 1) the relationship between specific genetic alterations in progressing gliomas and the evolving composition of the tumor microenvironment (TME) in parallel; and 2) how dynamic changes in the TME contribute to glioma recurrence following macrophage-targeted therapies. 

Background  

After I completed my Bachelor’s Degree (Health & Life Sciences) and Master’s Degree (Oncology) at the Free University of Amsterdam, Netherlands, I moved on to do my PhD in the lab of Prof. Jacco van Rheenen, at that time at the Hubrecht Institute, Utrecht, Netherlands. During my PhD, I studied the in vivo dynamics of single cells within heterogeneous tumors.

Rui SANTALLA MENDEZ
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Intern
CONTACT ME

Research interest 

During my PhD in the Joyce Lab, I aim to learn about immunology and cancer, two fields about which I am passionate. Specifically, I am interested in studying the relationship between immunity and angiogenesis in brain metastasis.

Background 

I obtained my BSc in Biomedical Sciences at University of Barcelona, Spain, and I completed my studies with an MSc in Immunology at Trinity College, Dublin, Ireland.

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CONTACT

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Johanna JOYCE
Full Professor
Ludwig member

Laboratory J. Joyce

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

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Phone +41 21 692 59 37
Email

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The Joyce Lab is based at:

AGORA Cancer Research Centre
Rue du Bugnon 25A
CH-1005 Lausanne
Switzerland

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)